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As today's society ages, age-related diseases become more frequent. One very common but yet preventable disease is the development of pressure ulcers (PUs). PUs can occur if tissue is exposed to a long-lasting pressure load, e.g., lying on tissue without turning. The cure of PUs requires intensive care, especially for the elderly or people with preexisting conditions whose tissue needs longer healing times. The consequences are heavy suffering for the patient and extreme costs for the health care system. To avoid these consequences, our objective is to develop a pressure ulcer prophylaxis device. For that, we built a new sensor system able to monitor the pressure load and tissue vital signs in immediate local proximity at patient's predilection sites. In the clinical study, we found several indicators showing correlations between tissue perfusion and the risk of PU development, including strongly reduced SpO2 levels in body tissue prior to a diagnosed PU. Finally, we propose a prophylaxis system that allows for the prediction of PU developments in early stages before they become visible. This work is the first step in generating an effective system to warn patients or caregivers about developing PUs and taking appropriate preventative measures. Widespread application could reduce patient suffering and lead to substantial cost savings.
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http://dx.doi.org/10.3390/bioengineering10101125 | DOI Listing |
PLoS One
September 2025
Department of Computer Science, Emory University, Atlanta, Georgia, United States of America.
Background: Erythema, an early visual indicator of tissue damage preceding pressure injuries (PrIs), presents as redness in light skin tones but is harder to detect in dark skin tones. While thermography shows promise for early PrI detection, validation across different skin tones remains limited. Furthermore, most protocols and models have been developed under highly controlled conditions.
View Article and Find Full Text PDFAngiogenesis
September 2025
Pathophysiology and Regenerative Medicine Group, Hospital Nacional de Parapléjicos, Servicio de Salud de Castilla la Mancha (SESCAM), 45071, Toledo, Spain.
Limited vascularization and ischemia are major contributors to the chronicity of wounds, such as ulcers and traumatic injuries, which impose significant medical, social, and economic burdens. These challenges are particularly pronounced in patients with spinal cord injury (SCI), a disabling condition associated with vascular dysfunction, infections, and impaired peripheral circulation, complicating the treatment of pressure injuries (PIs) and the success of reconstructive procedures like grafts and flaps. Regenerative medicine aims to address these issues by identifying effective cellular therapies to restore vascular beds.
View Article and Find Full Text PDFPEC Innov
June 2025
Division of Endocrinology, Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Objective: We aimed to measure the effect of implementing a pressure ulcer (PU) educational program on the knowledge and confidence of caregivers taking care of bedridden patients or patients with limited mobility.
Methods: This study included caregivers of immobile or bedridden patients in our center from 23 April 2023 to 13 May 2023. A pre-assessment questionnaire to assess knowledge about PUs was provided.
Front Dent Med
August 2025
Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Yinzhou No. 2 Hospital, Ningbo, Zhejiang, China.
Background: With the increase in the resident population and the number of children in Ningbo, as well as the growing demand for oral health care, the number of children's dental emergencies has been increasing year by year. This trend not only increases the pressure on medical resources, but also puts higher demands on the level of children's oral emergency care. In order to better guide the diagnosis and treatment of common and frequent diseases in paediatric oral emergency care, and to improve the efficiency of the use of medical resources.
View Article and Find Full Text PDFKhirurgiia (Mosk)
September 2025
Amur Regional Clinical Hospital, Blagoveshchensk, Russia.
The authors present treatment of patients with spinal injury complicated by extensive multiple pressure sores. A comprehensive preoperative management was followed by staged surgical treatment. Advisability of deep bedsore closure with full-layer flaps and staged interventions was justified.
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