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Study Objective: To investigate the efficacy of the perfusion index in assessing block success in pediatric patients undergoing elective supracondylar fracture repair surgery.
Methods: It was a retrospective study in a tertiary-care center. Twenty-eight pediatric supracondylar humerus fracture patients who underwent elective surgery for fracture repair were evaluated. Perfusion index, pulse rate, pleth variability index (PVi), and oxygen saturation were measured at different time intervals before and after the coracoid infraclavicular block procedure.
Main Results: The changes in perfusion index (PI) values were found to be statistically significant (p˂0.05). The Bonferroni analysis revealed that the results obtained at three separate measurement times differed significantly (p˂0.05). On the other hand, changes in other variables were not statistically significant (p˃0.05).
Conclusions: The perfusion index can be used as an indicator of block success in elective surgeries of the upper extremities in pediatric patients.
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http://dx.doi.org/10.7759/cureus.45281 | DOI Listing |
Br J Dermatol
September 2025
Population Health Program, QIMR Berghofer, Brisbane, Australia.
Background: Sunscreen reduces vitamin D production in experimental studies. It is uncertain whether this translates to 'real-world' settings.
Objectives: We aimed to dtermine if routinely applying high-SPF sunscreen for one year reduces serum 25-hydroxyvitamin D [25(OH)D] concentration.
iScience
September 2025
School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong 510006, China.
Deep learning has rapidly emerged as a promising toolkit for protein optimization, yet its success remains limited, particularly in the realm of activity. Moreover, most algorithms lack rigorous iterative evaluation, a crucial aspect of protein engineering exemplified by classical directed evolution. This study introduces DeepDE, a robust iterative deep learning-guided algorithm leveraging triple mutants as building blocks and a compact library of ∼1,000 mutants for training.
View Article and Find Full Text PDFBeilstein J Org Chem
August 2025
Latvian Institute of Organic Synthesis Aizkraukles 21, Riga, LV-1006, Latvia.
Alloc-protected furfuryl amino alcohols derived from furfural and ʟ- or ᴅ-valinol were subjected to Torii-type ester electrosynthesis to obtain the corresponding unsaturated esters. These served as key intermediates to prepare ()- and enantioenriched unsaturated amides by -Alloc deprotection which induced concomitant methoxymethyl group cleavage, to- rearrangement, and isomerization of the double bond. An oxazoline ring formation in the resulting unsaturated amides provided the corresponding enantioenriched vinyloxazoline.
View Article and Find Full Text PDFEur J Public Health
September 2025
Life Sciences Department, Barcelona Supercomputing Center, Barcelona, Spain.
The European Health Data Space (EHDS) will help researchers use health data across EU Member States (MS). Currently, cross-border research faces heterogeneous data access processes. Using a real-world use case, this paper analyses challenges and opportunities brought by the upcoming implementation of the EHDS, assessing the situation before and after the regulation comes into force.
View Article and Find Full Text PDFJMIR Res Protoc
September 2025
Moores Cancer Center, University of California, San Diego, La Jolla, CA, United States.
Background: Cancer screening nonadherence persists among adults who are deaf, deafblind, and hard of hearing (DDBHH). These barriers span individual, clinician, and health care system levels, contributing to difficulties understanding cancer information, accessing screening services, and following treatment directives. Critical communication barriers include ineffective patient-physician communication, limited access to American Sign Language (ASL) cancer information, misconceptions about medical procedures, insurance navigation difficulties, and intersectional barriers for multiply marginalized individuals.
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