Fishing for "complements" with vascular organoid models of microvascular disease.

Cell Stem Cell

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Yale Cooperative Center of Excellence in Hematology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: john.hwa@

Published: October 2023


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Article Abstract

In this issue of Cell Stem Cell, Kawakami et al. develop a SARS-CoV-2 infection-competent, progenitor-derived, human vascular organoid model and uncover a role for complement factor D (CFD) in mediating microvascular immunothrombosis. This model may be applied to conditions where microvascular disease plays a major pathogenic role.

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http://dx.doi.org/10.1016/j.stem.2023.09.004DOI Listing

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