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In this Correspondence, A. Sharma & C. Wolfrum report that DGAT1/2 pharmacological inhibition at post-absorptive phase in mice leads to increased fatty acid oxidation and reduced plasma fatty acid levels, which could open new therapeutic avenues to avoid GI complications observed in clinical trials.
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http://dx.doi.org/10.15252/emmm.202318209 | DOI Listing |
Mol Metab
August 2025
Université Paris Cité, BFA, UMR 8251, CNRS, Team « Endocrinology of Diabetes and Fertility », F-75013 Paris, France.
Objectives: Insulin deficiency caused by the loss of β cells and/or impaired insulin secretion is a key factor in the pathogenesis of type 2 diabetes (T2D). The restoration of β cell number and function is thus a promising strategy to combat diabetes. Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) has been shown to regulate human β cell proliferation.
View Article and Find Full Text PDFDiabet Med
September 2025
Mayo Clinic, Rochester, Minnesota, USA.
Skeletal muscle atrophy was a characteristic of type 1 diabetes (T1DM) prior to insulin discovery and replacement. Indirect calorimetry during the post-absorptive state demonstrated that increased fuel oxidation during transient insulin deprivation in T1DM caused depletion of energy stores. Further, insulin has a critical role in preserving muscle mitochondrial content and function by enhancing mitochondrial biogenesis and proteostasis.
View Article and Find Full Text PDFJ Anim Sci Biotechnol
February 2024
Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Background: Commercial diets are frequently formulated to meet or exceed nutrient levels including those of limiting essential amino acids (AA) covering potential individual variations within the herd. However, the provision of dietary excess of AA, such as Lys, may lead to reduced appetite and growth in pigs. The mechanisms modulating these responses have not been extensively investigated.
View Article and Find Full Text PDFEMBO Mol Med
November 2023
Laboratory of Translational Nutrition Biology, Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
In this Correspondence, A. Sharma & C. Wolfrum report that DGAT1/2 pharmacological inhibition at post-absorptive phase in mice leads to increased fatty acid oxidation and reduced plasma fatty acid levels, which could open new therapeutic avenues to avoid GI complications observed in clinical trials.
View Article and Find Full Text PDFAnimals (Basel)
October 2022
Large Animal Clinic, Veterinary Academy, Lithuanian University of Health Sciences, LT-47181 Kaunas, Lithuania.
Agriculture produces greenhouse gases. Methane is a result of manure degradation and microbial fermentation in the rumen. Reduced CH emissions will slow climate change and reduce greenhouse gas concentrations.
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