DGAT inhibition at the post-absorptive phase reduces plasma FA by increasing FA oxidation.

EMBO Mol Med

Laboratory of Translational Nutrition Biology, Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.

Published: November 2023


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Article Abstract

In this Correspondence, A. Sharma & C. Wolfrum report that DGAT1/2 pharmacological inhibition at post-absorptive phase in mice leads to increased fatty acid oxidation and reduced plasma fatty acid levels, which could open new therapeutic avenues to avoid GI complications observed in clinical trials.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630880PMC
http://dx.doi.org/10.15252/emmm.202318209DOI Listing

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