Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

The performance of the graphene-based field-effect transistor (FET) as a biosensor is based on the output drain current (I). In this work, the signal-to-noise ratio (SNR) was investigated to obtain a high-performance device that produces a higher I value. Using the finite element method, a novel top-gate FET was developed in a three-dimensional (3D) simulation model with the titanium dioxide-reduced graphene oxide (TiO-rGO) nanocomposite as the transducer material, which acts as a platform for biosensing application. Using the Taguchi mixed-level method in Minitab software (Version 16.1.1), eighteen 3D models were designed based on an orthogonal array L (63), with five factors, and three and six levels. The parameters considered were the channel length, electrode length, electrode width, electrode thickness and electrode type. The device was fabricated using the conventional photolithography patterning technique and the metal lift-off method. The material was synthesised using the modified sol-gel method and spin-coated on top of the device. According to the results of the ANOVA, the channel length contributed the most, with 63.11%, indicating that it was the most significant factor in producing a higher I value. The optimum condition for the highest I value was at a channel length of 3 µm and an electrode size of 3 µm × 20 µm, with a thickness of 50 nm for the Ag electrode. The electrical measurement in both the simulation and experiment under optimal conditions showed a similar trend, and the difference between the curves was calculated to be 28.7%. Raman analyses were performed to validate the quality of TiO-rGO.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10536288PMC
http://dx.doi.org/10.3390/mi14091664DOI Listing

Publication Analysis

Top Keywords

channel length
12
field-effect transistor
8
platform biosensing
8
length electrode
8
thickness electrode
8
electrode
6
geometrical characterisation
4
characterisation tio-rgo
4
tio-rgo field-effect
4
transistor platform
4

Similar Publications

In this study, we analyze InO thin-film transistors (InO-TFT) using synchrotron-based hard X-ray photoelectron spectroscopy (HAXPES) in conditions. A bottom-gate InO-TFT with a high- AlO gate dielectric, grown on thermally oxidized silicon (SiO/p-Si), was examined while operating at varying and . The results reveal that the In 3d core level binding energy varies along the horizontal channel length, driven by the potential gradient induced by .

View Article and Find Full Text PDF

The genus Flapocephalus Deshmukh, 1979, is a little-known group of lecanicephalidean cestodes parasitizing cowtail rays (genus Pastinachus Rüppell) mainly in the Indo-Pacific region. Since the erection of the genus, with Flapocephalus trygonis Deshmukh, 1979, as the type species, and the description of a second species, Flapocephalus saurashtri Shinde and Deshmukh, 1979, both from Pastinachus sephen (Fabricius) from India, reports of this genus have been restricted mainly to brief mentions or discussion of its validity and taxonomic placement. More recently, phylogenetic analyses based on molecular sequence data that included specimens of Flapocephalus have supported Flapocephalus as a distinct genus allied with the Polypocephalidae Meggitt, 1924.

View Article and Find Full Text PDF

Multilayer metal-organic frameworks-based artificial cytoskeleton for boosting immunosensors performance.

Biosens Bioelectron

September 2025

State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, PR China. Electronic address:

Artificial cytoskeletons are constructed to study the structure and function of eukaryotic cells. Metal-organic frameworks (MOFs) provide a strong foundation for the construction of artificial cytoskeleton by encapsulating enzyme, yet challenges such as random enzyme distribution and poor catalytic efficiency, impede the development of artificial cytoskeleton technologies. Herein, a multilayer MOFs-based programmable artificial cytoskeleton was constructed through a heterogeneous interfacial growth method, utilizing hierarchical encapsulation of enzymes to facilitate tandem biocatalytic reactions.

View Article and Find Full Text PDF

Skeletal patterning relies on a complex network of molecular and genetic regulators. However, our understanding of pathways governing joint placement and morphogenesis remains incomplete. Prior studies in have demonstrated that medially located Cx43 mediated gap junctional intercellular communication (GJIC) inhibits joint formation by the adjacent lateral skeletal precursor cells, and thereby determines skeletal patterning in the teleost regenerating fin.

View Article and Find Full Text PDF

Emergency department use of cross-channel TENS for acute low back pain: A randomized controlled trial.

Am J Emerg Med

August 2025

Department of Emergency Medicine, William Beaumont Army Medical Center, 18511 Highlander Medics Street, Fort Bliss, TX 79918, United States of America.

Background: Transcutaneous Electrical Nerve Stimulation (TENS) is established for chronic lower back pain but less studied in acute settings. This study evaluated the efficacy of cross-channel TENS for acute lower back pain in the emergency department (ED).

Methods: This single-blinded, randomized controlled trial enrolled ED patients aged 18-59 with acute lower back pain and Emergency Severity Index scores of 4 or 5.

View Article and Find Full Text PDF