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Chondral lesions of the knee are common orthopedic issues encountered in daily practice. Hyalofast (Anika Therapeutics, Bedford, Massachusetts) grafting with bone marrow aspirate concentrate (BMAC) has been shown, in numerous studies, to be clinically efficacious in the surgical treatment of these lesions. We describe a case of chondral lesions in the knee initially successfully treated with arthroscopic chondroplasty and Hyalofast grafting with BMAC, but who subsequently developed patellar cartilage bossing, causing anterior patellofemoral joint pain eight months after surgery. A 48-year-old gentleman underwent arthroscopic chondroplasty and mini-open cartilage repair with Hyalofast and BMAC after presenting with right knee pain and swelling affecting his ability to participate in sports. His initial recovery was unremarkable, but he subsequently developed anterior knee pain exacerbated by stair climbing and jogging eight months after the initial surgery. Magnetic resonance imaging revealed bossing of the Hyalofast graft over the central patella, and intraoperative testing confirmed the impingement. The patient's symptoms resolved immediately following arthroscopic debridement. While Hyalofast grafting and BMAC remain viable options in the treatment of chondral lesions in the knee, the inability to predict the amount of cartilage repair and recovery may result in pain and impingement symptoms, and surgeons should be aware of such possible complications.
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http://dx.doi.org/10.7759/cureus.43967 | DOI Listing |
Adv Healthc Mater
September 2025
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, P. R. China.
Osteoarthritis (OA) is a common degenerative joint disease, and early diagnosis and effective treatment are essential for managing its progression. This study focuses on the development of a novel drug delivery system using aggregation-induced emission (AIE) probe for enhanced fluorescence imaging and targeted therapy in OA. TPE-S-BTD, an AIE probe, is synthesized and characterized for its photophysical properties, demonstrating significant aggregation-induced fluorescence enhancement.
View Article and Find Full Text PDFACS Nano
September 2025
School of Medicine, Nankai University, Tianjin 300071, China.
In situ articular cartilage (AC) regeneration is a meticulously coordinated process. Microfracture has been the most extensive clinical approach in AC repair, but it faces challenges such as matrix degradation, generation, and remodeling within a local inflammatory microenvironment. So far, it remains a challenge to establish a multistage regulatory framework for coordinating these cellular events, particularly the immune response and chondrocyte proliferation in microfracture-mediated AC repair microenvironments, which is crucial for promoting AC regeneration quality.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Marine College, Shandong University, Weihai, 264209, China; Shandong Laboratory of Advanced Materials and Green Manufacturing, Yantai, 265599, China. Electronic address:
The treatment of chronic hard-to-heal wounds has become a major medical and public health problem worldwide. The search for novel and efficient wound healing dressings is crucial because of the complex mechanisms of wound genesis and of the inability to spontaneously repair. Many inherent properties of organisms in nature and their intrinsic molecular mechanisms have inspired researchers to design biomimetic hydrogel wound dressings to treat chronic hard-to-heal wounds.
View Article and Find Full Text PDFJ Thromb Haemost
September 2025
University of California San Diego, Department of Medicine, Division of Hematology/Oncology, La Jolla, CA, USA.
Background: Maladaptive lymphangiogenesis after hemarthrosis in Factor(F)VIII deficient (KO) mice facilitates synovial iron accumulation.
Objectives: To investigate the impact of FVIII treatment on lymphangiogenesis, iron clearance, and joint health after hemarthrosis.
Methods: Two days after knee injury/bleed (sub-patellar needle puncture) FVIII-KO mice were separated into three groups receiving (1) intravenous saline, (2) recombinant human (rh)FVIII for 2 days, or (3) murine (m)FcFVIII for 14 days.
Front Bioeng Biotechnol
August 2025
Institute of General Electrical Engineering, University of Rostock, Rostock, Germany.
Electrosensitive hydrogels are smart biomaterials that swell, shrink, deform, and bend when an external electric field is applied. These hydrogels have enormous potential for the controlled therapeutic delivery of biochemical substances to the affected area, thus promoting tissue regeneration. Computational modeling and simulation approaches have provided researchers with cost-effective predictive models that can be used to optimize and experimental protocols.
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