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Article Abstract
In recent decades, there has been a notable increase in antibiotic-resistant isolates, necessitating the development of innovative treatments to combat this pathogen. This manuscript explores the potential of different phage proteins to attenuate virulence factors of , particularly the type II secretion system (T2SS). PIT2, a protein derived from the lytic phage LMA2 inhibits the T2SS effectors PrpL and LasA and attenuates the bacterial virulence toward HeLa cells and . Using RNAseq-based differential gene expression analysis, PIT2's impact on the LasR regulatory network is revealed, which plays a key role in bacterial quorum sensing. This discovery expands our knowledge on phage-encoded modulators of the bacterial metabolism and offers a promising anti-virulence target in . As such, it lays the foundation for a new phage-inspired anti-virulence strategy to combat multidrug resistant pathogens and opens the door for SynBio applications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509696 | PMC |
| http://dx.doi.org/10.1016/j.isci.2023.107745 | DOI Listing |
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