Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
This report describes the case of a 76-year-old man with ulcerative colitis who developed interstitial nephritis after starting 5-Aminosalicylic acid (5-ASA) therapy. The patient experienced an initial improvement in symptoms, but developed fatigue, anorexia, and severe renal dysfunction 2.5 months later. Renal biopsy confirmed drug-induced interstitial nephritis, and conservative treatment with fluid replacement and the discontinuation of 5-ASA improved the patient's condition. Clinicians should monitor patients receiving 5-ASA therapy for potential adverse effects, particularly renal injury, and promptly investigate symptoms of renal dysfunction. Early recognition and discontinuation of the offending agent may prevent further damage and improve patient outcomes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11081892 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.2366-23 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tubulointerstitial Nephritis Post-Microsporidium Infection in a Combined Liver-Kidney Transplanted Patient: A Case Report.
Nephrology (Carlton)
September 2025
Department of Medical Microbiology & Immunology, University of Alberta, Edmonton, Alberta, Canada.
Microsporidia are emerging opportunistic pathogens in immunosuppressed individuals, including solid organ transplant recipients. We present a case of tubulointerstitial nephritis (TIN) caused by Microsporidia infection in a 55-year-old male who underwent combined liver-kidney transplantation (CLKT) for metabolic-associated fatty liver disease and end-stage kidney disease. The patient developed diarrhoea, abdominal bloating and acute kidney injury (AKI) 1 month post-transplant.
View Article and Find Full Text PDFSurvey of Coyotes for Vector-Borne and Bacterial Pathogens in South Carolina and Tennessee, USA.
J Wildl Dis
September 2025
Biomedical and Diagnostic Sciences, University of Tennessee, 2407 River Drive, Room A233, Knoxville, Tennessee 37996, USA.
Coyotes (Canis latrans) can serve as hosts for many pathogens of concern and may be useful for monitoring the prevalence and emergence of these pathogens. We collected serum and/or whole blood antemortem from 43 coyotes from South Carolina, US, and collected samples from opportunistically collected carcasses from 71 Tennessee, US and 15 South Carolina, US coyotes. We tested samples with SNAP 4Dx PLUS rapid ELISA tests for Ehrlichia spp.
View Article and Find Full Text PDFSubclinical tubular kidney injury associated with immune checkpoint inhibitors and cisplatin treatment: Diagnosis through urinary biomarkers.
Biomed Pharmacother
September 2025
Toxicology Unit, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, Salamanca 37007, Spain; Institute of Biomedical Research of Salamanca (IBSAL), Paseo de San Vicente 182, Salamanca 37007, Spain; Group of Translational Research on Renal and Cardiovascular Diseases (TRECARD)
Immune checkpoint inhibitors (ICIs) represent a major advance in cancer treatment due to their efficacy and safety profile. However, they are not free of side effects, including nephrotoxicity, which worsens prognosis. Diagnosis of renal injury based on clinical findings has limitations in predicting and identifying the type of damage.
View Article and Find Full Text PDFAcute Tubulointerstitial Nephritis (ATIN) in Patient With Autosomal Dominant Polycystic Kidney Disease (ADPKD): A Case Report.
Case Rep Nephrol
August 2025
Department of Nephrology, Faculty of Medicine, Damascus University, Damascus, Syria.
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by diffuse renal cysts that secrete cytokines, which induce interstitial inflammation and fibrosis. Meanwhile, acute tubulointerstitial nephritis (ATIN) is characterized by inflammatory infiltrates in the interstitium, where kidney biopsy remains the mainstay for diagnosis. An 85-year-old male complained of fatigue, loss of appetite, and low-grade fever for a week.
View Article and Find Full Text PDFSevere Rhabdomyolysis Due to Presumed Drug Interactions of Dapagliflozin with Rosuvastatin: A Case Report.
Indian J Nephrol
June 2024
Department of Pathology, Aster Whitefield, Bengaluru, India.
Sodium-glucose-cotransporter-2 inhibitors (SGLT2i) and statins are increasingly used for reduction of cardiovascular mortality in type 2 diabetics. Few case studies reported an enhanced risk of rhabdomyolysis with this combination. A 57-year-old man with normal renal functions, developed fatigue and oliguria within three days of dapagliflozin addition to his preexistent rosuvastatin therapy.
View Article and Find Full Text PDF