Publications by authors named "Satoru Okabe"
Background: Covered self-expandable metal stents (SEMS) are the standard for managing unresectable distal malignant biliary obstruction (DMBO), as they prolong the time to recurrent biliary obstruction (TRBO). However, fully covered SEMS (FCSEMS) increases the risk of cholecystitis and pancreatitis. This exploratory study evaluated a novel multihole partially covered SEMS (MHSEMS) designed to reduce these risks.
View Article and Find Full Text PDFImpact of time from diagnosis to chemotherapy on prognosis in advanced pancreatic cancer.
Jpn J Clin Oncol
June 2024
Article Synopsis
- Advanced pancreatic cancer requires quick treatment; the study looked at how the time between diagnosis and starting chemotherapy affects patient survival.
- A total of 137 patients were analyzed, split into two groups: those starting treatment within 30 days and those waiting longer.
- The results showed no significant survival difference between the groups, suggesting that waiting more than 30 days to begin chemotherapy does not adversely impact treatment effectiveness.
5-Aminosalicylic Acid-Induced Liver Injury in a Patient with Ulcerative Colitis: A Case Report.
Case Rep Gastroenterol
January 2024
Article Synopsis
- Drug-induced liver injury (DILI) from 5-aminosalicylic acid (5-ASA) is a rare but serious condition, as illustrated by a case of a 58-year-old woman with ulcerative colitis who experienced severe liver enzyme elevation after starting treatment.
- Diagnostic tests, including blood tests and a liver biopsy, indicated acute lobular hepatitis and raised concerns about autoimmune hepatitis, leading to the discontinuation of 5-ASA.
- The patient's liver function improved with treatment, stressing the need for careful monitoring of liver health in individuals undergoing 5-ASA therapy.
This report describes the case of a 76-year-old man with ulcerative colitis who developed interstitial nephritis after starting 5-Aminosalicylic acid (5-ASA) therapy. The patient experienced an initial improvement in symptoms, but developed fatigue, anorexia, and severe renal dysfunction 2.5 months later.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the impact of antithrombotic drugs (ATs) on fecal immunochemical test (FIT) results for colorectal cancer (CRC) screening, comparing results between AT users and nonusers.
- Findings indicate that patients on ATs had lower adenoma detection rates (ADRs) and polyp detection rates (PDRs), though the overall predictive value for detecting invasive CRC remained similar.
- Notably, the use of warfarin was identified as a potential positive predictive factor for invasive CRC detection among AT users, suggesting it might have some influence on FIT outcomes.
Predictive factors of collateral vessel development induced by oxaliplatin-based chemotherapy.
Int J Clin Oncol
February 2023
Background And Aim: Oxaliplatin can lead to hepatic sinusoidal injury, called hepatic sinusoidal obstruction syndrome (SOS), resulting in portal hypertension-related complications. This could worsen the clinical course of the patients treated with oxaliplatin. Early diagnosis is challenging.
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