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Exercise-induced desaturation is common in patients with moderate to severe chronic obstructive pulmonary disease (COPD). It provides additional information about physical capacity and disease evolution, and it is an important predictor of mortality.
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http://dx.doi.org/10.3897/folmed.65.e85983 | DOI Listing |
Radiology
September 2025
Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Plc, Box 1234, New York, NY 10029.
Background The prognostic value of baseline visual emphysema scoring at low-dose CT (LDCT) in lung cancer screening cohorts is unknown. Purpose To determine whether a single visual emphysema score at LDCT is predictive of 25-year mortality from all causes, chronic obstructive pulmonary disease (COPD), and cardiovascular disease (CVD). Materials and Methods In this prospective cohort study, asymptomatic adults aged 40-85 years with a history of smoking underwent baseline LDCT screening for lung cancer between June 2000 and December 2008.
View Article and Find Full Text PDFGen Physiol Biophys
September 2025
Pneumology Department, Zigong First People's Hospital, Zigong, China.
Chronic obstructive pulmonary disease (COPD) is characterized by airway remodeling and inflammation. Cigarette smoke extract (CSE) induces apoptosis, inflammation, and oxidative stress in COPD. Tripterygium glycosides (TG) are an active compound found in the root extracts of Tripterygium wilfordii Hook F (TWHF) that possesses anti-inflammatory and immunosuppressive effects.
View Article and Find Full Text PDFJ Investig Med
September 2025
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, Qiaoxi District, Zhangjiakou, China.
BackgroundWe explored the potential impact of testosterone treatment in a male rat model of chronic obstructive pulmonary disease (COPD). Our study focused on evaluating the potential decrease in the expression and activation of matrix metalloproteinase-9 (MMP-9) and fibroblast growth factor-23 (FGF-23) induced by COPD.MethodsWistar rats were randomly assigned to one of three groups: control, COPD, or testosterone treatment.
View Article and Find Full Text PDFTher Adv Respir Dis
September 2025
Department of Respiratory Medicine, Shangyu People's Hospital of Shaoxing, Zhejiang, China.
Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition associated with increased morbidity and mortality, particularly during respiratory infections such as influenza. The interaction between COPD and influenza is multifaceted, involving compromised immune responses, chronic inflammation, and impaired lung function. Influenza infection can exacerbate COPD, leading to acute exacerbations, hospitalizations, and higher mortality.
View Article and Find Full Text PDFMonaldi Arch Chest Dis
July 2025
Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi.
Ladakh is a hilly Himalayan dry desert, situated at an altitude of >11,000 feet. Studies have demonstrated that the spirometric values of high-altitude residents are significantly higher than those of low landers. This is a retrospective observational study that analyzes the spirometry pattern in chronic lung diseases among people from Ladakh.
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