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As a high energy density power system, lithium-carbon dioxide (Li-CO ) batteries play an important role in addressing the fossil fuel crisis issues and alleviating the greenhouse effect. However, the sluggish transformation kinetic of CO and the difficult decomposition of discharge products impede the achievement of large capacity, small overpotential, and long life span of the batteries, which require exploring efficient catalysts to resolve these problems. In this review, the main focus is on the hot spot regulation strategies of the catalysts, which include the modulation of the active sites, the designing of microstructure, and the construction of composition. The recent progress of promising catalysis with hot spot regulated strategies is systematically addressed. Critical challenges are also presented and perspectives to provide useful guidance for the rational design of highly efficient catalysts for practical advanced Li-CO batteries are proposed.
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http://dx.doi.org/10.1002/smll.202305009 | DOI Listing |
Talanta
August 2025
School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, PR China. Electronic address:
Abnormal cellular Cu level is closely associated with many various pathological conditions, including cancer, Menkes disease, and Wilson's disease. However, sensitive and accurate detection of intracellular Cu remains challenging. To address this, we engineered an interference-free surface-enhanced Raman scattering (SERS) nanoprobe utilizing a target-responsive aggregation mechanism for selective Cu detection.
View Article and Find Full Text PDFMar Environ Res
August 2025
Istanbul University, Institute of Marine Science and Management, Vefa, 34134, Istanbul, Turkey.
Bisphenol analogues and phthalate acid esters are well-known endocrine disruptors. Information on detailed distribution and partitioning of Bisphenol A (BPA) and Phthalate acid esters (PAEs) in port sediments is essential for a better understanding of their residence time in sediment, influence of anthropogenic activities in port, and port sustainability, especially in terms of environmental impact. Herein, this study determined the concentrations of BPA and PAEs in sediments that are collected from 38 stations from Istanbul ship-ports and scrutinized distribution, possible source identification and potential environmental risk assessment.
View Article and Find Full Text PDFBreast Cancer Res
September 2025
Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Ki67 is a broadly available biomarker of proliferation with various approaches to its evaluation in breast cancer. The International Ki67 in Breast Cancer Working Group (IKWG) recommends calculating Ki67 globally across the tumor area, as this method offers high interobserver concordance. These recommendations have been integrated into many international breast cancer guidelines (ASCO, ESMO), yet there is no real-world data on if it improved inter-pathologists and inter-laboratory variability.
View Article and Find Full Text PDFInterdiscip Sci
September 2025
State Key Laboratory of Microbial Metabolism, Shanghai-Islamabad-Belgrade Joint Innovation Center on Antibacterial Resistances, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, C
Protein-protein interactions (PPIs) are essential therapeutic targets, yet their large and relatively flat interfaces hinder the development of small-molecule inhibitors. Traditional computational approaches rely heavily on existing chemical libraries or expert heuristics, restricting exploration of novel chemical space. To address these challenges, we present Hot2Mol, a generative deep learning framework for the de novo design of target-specific and drug-like PPI inhibitors.
View Article and Find Full Text PDFJ Med Chem
September 2025
Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.
Dengue viruses (DENVs) infect approximately 400 million people each year, and currently, there are no effective therapeutics available. To explore potential starting points for antiviral drug development, we conducted a large-scale crystallographic fragment screen targeting the RNA-dependent RNA polymerase (RdRp) domain of the nonstructural protein 5 (NS5) from DENV serotype 2. Our screening, which involved 1108 fragments, identified 60 hit compounds across various known binding sites, including the active site, N pocket, and RNA tunnel.
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