Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A perimetastatic capsule is a strong positive prognostic factor in liver metastases, but its origin remains unclear. Here, we systematically quantify the capsule's extent and cellular composition in 263 patients with colorectal cancer liver metastases to investigate its clinical significance and origin. We show that survival improves proportionally with increasing encapsulation and decreasing tumor-hepatocyte contact. Immunostaining reveals the gradual zonation of the capsule, transitioning from benign-like NGFR stroma at the liver edge to FAP stroma towards the tumor. Encapsulation correlates with decreased tumor viability and preoperative chemotherapy. In mice, chemotherapy and tumor cell ablation induce capsule formation. Our results suggest that encapsulation develops where tumor invasion into the liver plates stalls, representing a reparative process rather than tumor-induced desmoplasia. We propose a model of metastases growth, where the efficient tumor colonization of the liver parenchyma and a reparative liver injury reaction are opposing determinants of metastasis aggressiveness.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439160 | PMC |
| http://dx.doi.org/10.1038/s41467-023-40688-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Surgical strategy for repeated metastasectomy for advanced colorectal cancer with synchronous liver metastases.
Surg Today
September 2025
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8588, Japan.
Purpose: Liver metastases from colorectal cancer (CRLM) are a major determinant of the prognosis of metastatic colorectal cancer. Although curative resection is recommended for resectable CRLM, recurrence remains a challenge and the criteria for patient selection and repeat resection are still unclear. We conducted this study to evaluate the outcomes of metastatic lesion resection with curative intent (R0 resection), to identify the factors associated with recurrence, and to establish the feasibility of repeat metastasectomy.
View Article and Find Full Text PDFLaparoscopic Microwave Ablation vs Resection for Small Solitary Colorectal Liver Metastases: Multicenter Analysis of Long-Term Results.
J Am Coll Surg
September 2025
Departments of Endocrine and General Surgery, Cleveland Clinic, Cleveland, OH.
Background: Although traditionally reserved for unresectable lesions, recent studies have provided evidence that in selected patients, microwave ablation (MWA) may provide similar oncologic outcomes compared to liver resection (LR). This study aimed to compare oncologic outcomes of patients with solitary small (<3 cm) colorectal liver metastasis (CRLM) undergoing LR vs laparoscopic MWA.
Study Design: This retrospective study included patients with a solitary CRLM <3cm treated with LR or MWA in three centers over 25-years.
Pediatric Alpha-Fetoprotein-Producing Gastric Cancer Presenting With Dysphagia and Multiple Liver Tumors.
Cancer Rep (Hoboken)
September 2025
Department of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan.
Background: Alpha-fetoprotein (AFP)-producing gastric cancer (AFPGC) is resistant to chemotherapy and is associated with poor prognosis. Pediatric gastric cancer has an incidence of 0.02% among gastric cancer patients, with a median survival of 5 months.
View Article and Find Full Text PDFTreatment consequence and adverse events of cyclin-dependent kinase 4/6 inhibitors on patients with hormone receptor-positive, HER2-negative metastatic breast cancer: a systematic review and meta-analysis.
Ann Med
December 2025
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Background: Although some studies have indicated that CDK4/6 inhibitors are beneficial for the progression-free survival (PFS) and overall survival (OS) in breast cancer, evidence regarding the assessment of clinical response remains insufficient. Therefore, this study aims not only to evaluate the efficacy and safety of CDK4/6 inhibitors combined with endocrine therapy in HR(+)/HER2(-) metastatic breast cancer, but also to analyze the objective response rate (ORR) and clinical benefit rate (CBR), providing comprehensive clinical outcome insights.
Materials And Methods: A literature search was performed in PubMed, Embase, Cochrane Library, and ClinicalTrials.
Free-breathing phase-sensitive inversion recovery T-weighted imaging for improved visualization of focal liver lesions.
Magn Reson Med
September 2025
Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Purpose: Gadoxetic acid-enhanced hepatobiliary phase T-weighted (Tw) MRI is effective for the detection of focal liver lesions but lacks sufficient T contrast to distinguish benign from malignant lesions. Although the addition of T, diffusion, and dynamic contrast-enhanced Tw imaging improves lesion characterization, these methods often do not provide adequate spatial resolution to identify subcentimeter lesions. This work proposes a high-resolution, volumetric, free-breathing liver MRI method that produces colocalized fat-suppressed, variable Tw images from a single acquisition, thereby improving both lesion detection and characterization.
View Article and Find Full Text PDF