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Ovules are precursors of seeds and contain sporophytic integuments and gametophytic embryo sac. In Arabidopsis, embryo sac development requires highly synchronized morphogenesis of integument such that defects in integument growth often accompanies with a block in megagametogenesis, indicating that integument instructs the development of female gametophytes. In this mini review, we discuss signaling pathways through which integument cells mediate embryo sac development. We also propose ways to identify key signaling factors for the communication between integument and developing female gametophyte.
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http://dx.doi.org/10.1016/j.plantsci.2023.111829 | DOI Listing |
Ultrasound Obstet Gynecol
September 2025
Department of Clinical Genetics, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.
Objective: To evaluate the performance of non-invasive prenatal testing (NIPT) in vanishing-twin and multiple pregnancies.
Methods: This study was conducted as part of the TRIDENT-2 study, in which NIPT was offered as a first-tier screening test to women with a multiple pregnancy or vanishing-twin pregnancy between 1 June 2020 and 31 March 2023 in The Netherlands. Abnormal NIPT results were investigated by follow-up invasive prenatal testing and/or postnatal genetic testing.
Genome Biol
September 2025
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Background: A growing body of evidence from primate embryos as well as in vitro systems supports the notion that amnion and primordial germ cell (PGC) lineage progressing cells share a common precursor.
Results: To gain comprehensive transcriptomic insights into this critical but poorly understood precursor and its progeny, we examine the evolving transcriptome of a developing human pluripotent stem cell-derived model of amnion and PGC formation at the single cell level. This analysis reveals several continuous amniotic fate progressing states with state-specific markers.
J Korean Med Sci
September 2025
Department of Pediatrics, Keimyung University Dongsan Hospital, Daegu, Korea.
Background: Preeclampsia (PE) is a hypertensive disorder and a major cause of maternal and fetal mortality. We aimed to investigate the molecular properties of early-onset PE, which requires delivery before 34 weeks' gestation by analyzing the molecular cytokine profile of amniotic fluid obtained during cesarean section from pregnant women with early-onset PE, based on the presence or absence of small-for-gestational age (SGA).
Methods: This study included 73 pregnant women with early-onset PE among which 21 women had SGA infants, whose birth weight was less than the 10th percentile of the gestational age-specific birth weight.
Cell Stem Cell
August 2025
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texa
Early post-implantation human development is poorly understood due to limited access to natural embryos. Integrated stem cell-based embryo models (SCBEMs) offer an alternative, but current models face challenges in reproducibility, efficiency, and genomic stability. Here, we developed inducible SCBEMs (iSCBEMs) by combining primed human pluripotent stem cells (hPSCs) with transgene-induced extraembryonic cells derived from naive hPSCs.
View Article and Find Full Text PDFBiomedicines
July 2025
Neurosurgical Institute, University of Ioannina, 45110 Ioannina, Greece.
Haloperidol is a typical antipsychotic drug widely used for acute confusional state, psychotic disorders, agitation, delirium, and aggressive behavior. The toxicity of haloperidol was studied using zebrafish (ZF) embryos as a model organism. Dechorionated embryos were exposed to various concentrations of haloperidol (0.
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