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Background: Septic arthritis (SA) in children is an acute inflammatory disease of the joints. If not treated promptly, it could become a surgical emergency. The incidence of the disease in children in Europe is approximately 2-7 per 100,000 children. The aim of this systematic review was to investigate which of these treatments-arthrocentesis, arthrotomy, and arthroscopy-provides better results in children and when to use them.
Methods: Three independent authors conducted a systematic review of PubMed, ScienceDirect, and MEDLINE databases to assess studies with any level of evidence that reported the surgical outcome of SA. Two senior investigators evaluated and approved each stage's findings.
Results: A total of 488 articles were found. After screening, we chose 24 articles that were suitable for full-text reading based on the inclusion and exclusion criteria. The results of our analysis showed that there are no numerically significant differences reported in the literature on clinical and radiographic outcomes by surgical technique.
Conclusions: We developed an algorithm that could be used if septic arthritis is suspected. Based on our results, the surgical technique to be used will depend on the operator who will perform it.
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http://dx.doi.org/10.3390/jpm13071097 | DOI Listing |
Can Vet J
September 2025
Faculté de Médecine Vétérinaire, Université de Montréal, 3200, rue Sicotte, Saint-Hyacinthe (Québec) J2S 2M2.
Debilitated calves are often presented with an umbilical remnant infection, septic arthritis, or both. These comorbidities, frequently caused by similar bacteria, must be addressed surgically. In cases of omphalophlebitis where the infection reaches the liver, the clinician generally has 1 option: marsupialization of the vein.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute and Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom.
MS4A4A belongs to the MS4A tetraspan protein superfamily and is selectively expressed by the monocyte-macrophage lineage. In this study, we aimed to evaluate the role of MS4A4A+ macrophages in rheumatoid arthritis (RA) pathogenesis and response to treatment. RNA sequencing and immunohistochemistry of synovial samples from either early treatment-naïve or active chronic RA patients showed that MS4A4A expression positively correlated with synovial inflammation.
View Article and Find Full Text PDFOman Med J
March 2025
Department of Family Medicine and Public Health, Sultan Qaboos University, Sultan Qaboos University Hospital, Oman.
Zoledronic acid is commonly used to treat osteoporosis and it is generally well tolerated. We describe the case of a woman with osteoporosis, who developed a flare-up of osteoarthritis hours after receiving a single dose of zoledronic acid. She developed fever with chills, generalized body aches, and severe low back pain.
View Article and Find Full Text PDFDiabetes Obes Metab
September 2025
Phase I Clinical Trial Research Ward, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, People's Republic of China.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is an emerging global health concern, and its presence increases the risk of multi-system diseases. This study aimed to investigate the multimorbidity trajectories of chronic diseases in people living with MASLD.
Methods: We identified 137 859 MASLD patients in UK Biobank and used 'propensity score matching' to match an equal number of non-MASLD controls.
Cureus
September 2025
Medicine, University of Arizona College of Medicine, Phoenix, USA.
Ixekizumab, an IL-17A inhibitor, is commonly used to treat moderate-to-severe plaque psoriasis and psoriatic arthritis, with a well-documented risk of mucocutaneous infections, though its role in bacterial infections is less defined. We present the case of a 62-year-old male on ixekizumab who developed scrotal cellulitis with subsequent septic thrombophlebitis, despite no clear entry point. His condition initially improved with broad-spectrum antibiotics, but later worsened, requiring further imaging and multidisciplinary management.
View Article and Find Full Text PDF