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Over the last decade, video-enabled mobile devices have become ubiquitous, while advances in markerless pose estimation allow an individual's body position to be tracked accurately and efficiently across the frames of a video. Previous work by this and other groups has shown that pose-extracted kinematic features can be used to reliably measure motor impairment in Parkinson's disease (PD). This presents the prospect of developing an asynchronous and scalable, video-based assessment of motor dysfunction. Crucial to this endeavour is the ability to automatically recognise the class of an action being performed, without which manual labelling is required. Representing the evolution of body joint locations as a spatio-temporal graph, we implement a deep-learning model for video and frame-level classification of activities performed according to part 3 of the Movement Disorder Society Unified PD Rating Scale (MDS-UPDRS). We train and validate this system using a dataset of n = 7310 video clips, recorded at 5 independent sites. This approach reaches human-level performance in detecting and classifying periods of activity within monocular video clips. Our framework could support clinical workflows and patient care at scale through applications such as quality monitoring of clinical data collection, automated labelling of video streams, or a module within a remote self-assessment system.
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http://dx.doi.org/10.1109/JBHI.2023.3298530 | DOI Listing |
Adv Sci (Weinh)
September 2025
Department of Physics, State Key Laboratory of Surface Physics, and Key Laboratory for Computational Physical Science (Ministry of Education), Fudan University, 2005 Songhu Road, Yangpu District, Shanghai, 200433, China.
Emerging evidence indicates that liquid-liquid phase separation of α-synuclein occurs during the nucleation step of its aggregation, a pivotal step in the onset of Parkinson's disease. Elucidating the molecular determinants governing this process is essential for understanding the pathological mechanisms of diseases and developing therapeutic strategies that target early-stage aggregation. While previous studies have identified residues critical for α-synuclein amyloid formation, the key residues and molecular drivers of its phase separation remain largely unexplored.
View Article and Find Full Text PDFMov Disord Clin Pract
September 2025
Department of Neurology, Danish Dementia Research Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Background: Early identification of pathological α-synuclein deposition (αSynD) may improve understanding of Lewy body disorder (LBD) progression and enable timely disease-modifying treatments.
Objectives: We investigated αSynD using a seed amplification assay and assessed prodromal LBD symptoms in individuals with idiopathic olfactory dysfunction (iOD).
Methods: In this cross-sectional, case-control study, we included iOD participants and normosmic healthy controls (HC) aged 55 to 75 years without diagnoses of dementia with Lewy bodies, Parkinson's disease (PD), or other major neurological disorders.
Parkinson's disease (PD) is the fastest-growing neurodegenerative disease in the world and appears to be an emerging epidemic in Africa, where counteractive measures have become necessary. Previous reports have highlighted the limited epidemiological and clinical PD research in Africa but overlooked the poor preclinical PD research output of the continent. Because preclinical research is a bedrock for translating basic scientific research into clinical practice, a weak preclinical research foundation can hamper advancement in epidemiological and clinical investigations.
View Article and Find Full Text PDFMov Disord Clin Pract
September 2025
Department of Neurology, Parkinson's Disease and Movement Disorders Center, Northwestern University, Chicago, Illinois, USA.
Crit Rev Anal Chem
September 2025
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India.
Neurodegenerative disorders (NDD) i.e., dementia of the Alzheimer's type, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are a rising worldwide epidemic driven by aging populations and characterized by progressive neuronal impairment.
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