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http://dx.doi.org/10.1007/s12098-023-04775-7 | DOI Listing |
Diagnostics (Basel)
August 2025
School of Medicine, Aristotle University of Thessaloniki (AUTH), 54124 Thessaloniki, Greece.
IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis worldwide, with a heterogeneous clinical course that may progress to end-stage kidney disease (ESKD) in approximately 20% of patients. Despite recent advances, including the U.S.
View Article and Find Full Text PDFMedicina (Kaunas)
August 2025
Department of Nephrology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.
: This study aimed to explore the risk factors of histopathological crescent formation in pediatric IgA vasculitis nephritis (IgAVN). : Enrolled patients with biopsy-proven IgAVN from Zhejiang University's hospital were split into two groups: 377 with no crescents on histopathology (Group 1) and 364 with crescentic nephritis (Group 2). Collected data included clinical features, lab indicators, histopathological grading, and factors causing glomerular sclerosis.
View Article and Find Full Text PDFKidney Int Rep
August 2025
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Introduction: IgA nephropathy (IgAN) recurs frequently in kidney transplants, although the reported frequency of recurrence varies because many studies do not distinguish recurrent IgAN from IgAN occurring in the allograft. In addition, there are only limited studies of graft outcomes in patients with recurrent IgAN.
Methods: We retrospectively examined 264 kidney transplant biopsies with glomerular IgA deposits, distinguishing whenever possible recurrent versus IgAN, and compared clinical and pathologic features of biopsies of patients within these groups.
BMC Nephrol
August 2025
İstanbul Faculty of Medicine, Department of Nephrology, İstanbul University, İstanbul, Türkiye.
Background: ANCA-associated glomerulonephritis (ANCA-GN) is a leading cause of pauci-immune crescentic GN. Recent evidence indicates that complement activation, marked by C3 deposition in glomeruli, may contribute to more severe renal injury and influence renal outcomes. We aim to evaluate the clinical, histopathological, and prognostic implications of C3 deposition in ANCA-GN.
View Article and Find Full Text PDFKidney Int Rep
July 2025
Renal Division, Peking University First Hospital, Beijing, China.