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http://dx.doi.org/10.1016/j.jgg.2023.07.003 | DOI Listing |
Brain Behav
September 2025
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction: Inflammatory cytokine disturbance is a prominent outcome of immune dysregulation, extensively documented in bipolar disorder (BD). However, observational studies have exhibited inconsistent findings, and the causal relationships between inflammatory factors and BD remain unclear. Hence, this study aimed to uncover the causality between circulating inflammatory cytokines and BD.
View Article and Find Full Text PDFJ Plant Physiol
September 2025
State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, 430062, China. Electronic address:
RAV transcription factors play roles in a variety of diverse biological processes. However, their role in rice's response to drought and blast stress remains largely unexplored. In this study, we performed a genome-wide characterization and identification of rice RAV transcription factor family genes.
View Article and Find Full Text PDFCerebrovasc Dis
September 2025
Background: Intracranial aneurysm (IA), known as pathological dilation of cerebral arteries,commonly occurring at bifurcating arteries,carries a high risk of severe morbidity and mortality if left untreated.Although the treatment and early diagnosis have significantly improved,the complex pathophysiological process of IA formation presents significant challenges in the development of targeted therapies.Efficient disease-modifying therapies for IA are not yet available.
View Article and Find Full Text PDFJ Clin Periodontol
September 2025
Institute of Health Services Research in Dentistry, University of Münster, Münster, Germany.
Background And Objective: Periodontitis is a chronic inflammatory disease driven by immune dysfunction and microbial imbalance. This study aims to identify circulating druggable proteins causally linked to the disease.
Materials And Methods: We integrated proteomics data from deCODE genetics with periodontitis genome-wide association studies (GWAS) from the Million Veteran Program to identify proteins associated with periodontitis.
Curr Gene Ther
August 2025
Amity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow Campus, Lucknow, Uttar Pradesh, India.
Crohn's disease (CD), a chronic inflammatory disorder of the gastrointestinal tract, presents significant challenges in clinical medicine due to its multifactorial etiology and varied therapeutic responses. This review examines the diverse causes of CD, including genetic predispositions identified through genome-wide association studies (GWAS), which involve scanning the genome for single-nucleotide polymorphisms associated with CD risk, as well as environmental triggers, such as diet and alterations in the microbiome. Biomarkers, such as fecal calprotectin and Creactive protein (CRP), as well as genetic markers like NOD2 mutations, provide critical tools for diagnosis and treatment stratification.
View Article and Find Full Text PDF