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http://dx.doi.org/10.1136/rapm-2023-104457 | DOI Listing |
Acc Chem Res
September 2025
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada.
ConspectusHydroaminoalkylation, the catalytic addition of amines to alkenes, has evolved as a powerful tool in modern synthetic chemistry, offering an atom-economic and green approach to the construction of C-C bonds. This reaction enables the direct amine functionalization of alkenes and alkynes without the need for protecting groups, directing groups, or prefunctionalization, thereby eliminating stoichiometric waste and minimizing synthetic steps. Over the past two decades, significant advances in catalyst development and mechanistic understanding have expanded the scope of hydroaminoalkylation, allowing for control over regio-, diastereo-, and enantioselectivity.
View Article and Find Full Text PDFiScience
September 2025
School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong 510006, China.
Deep learning has rapidly emerged as a promising toolkit for protein optimization, yet its success remains limited, particularly in the realm of activity. Moreover, most algorithms lack rigorous iterative evaluation, a crucial aspect of protein engineering exemplified by classical directed evolution. This study introduces DeepDE, a robust iterative deep learning-guided algorithm leveraging triple mutants as building blocks and a compact library of ∼1,000 mutants for training.
View Article and Find Full Text PDFJ Coord Chem
August 2025
Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT, USA.
Dipyrrin has proven to be a versatile ligand platform for metals across the periodic table. Since much of the coordination chemistry has focused on transition metals, main-group dipyrrin chemistry has been underexplored, particularly in the case of heavy p-block elements. Boron dipyrrin complexes (also known as BODIPY) were initially reported in 1968, yet the first well-characterized example of a heavy p-block dipyrrin complex was in 2006.
View Article and Find Full Text PDFPhys Chem Chem Phys
September 2025
Institute of Low Temperature Science, Hokkaido University, Sapporo, Japan.
Molecules are ubiquitous in space. They are necessary components in the creation of habitable planetary systems and can provide the basic building blocks of life. Solid-state processes are pivotal in the formation of molecules in space and surface diffusion in particular is a key driver of chemistry in extraterrestrial environments, such as the massive clouds in which stars and planets are formed and the icy objects within our solar system.
View Article and Find Full Text PDFFitoterapia
August 2025
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru 570 015, Karnataka, India. Electronic address:
From past to the present, plants and trees have benefited humans in many ways. As technology advanced the biological properties of plants are much more explored especially by the pharma industry. Rosemary plant has gained attention as a phytoconstituent-rich herb that may help to manage diabetes mellitus (DM), however, exact mechanism of action is still unknown.
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