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In recent decades, the Surface Plasmon Resonance (SPR) phenomenon has been utilized as an underlying technique in a broad range of application fields. Herein, a new measuring strategy which harnesses the SPR technique in a way that is different from the classical methodology was explored by taking advantage of the characteristics of multimode waveguides, such as plastic optical fibers (POFs) or hetero-core fibers. The sensor systems based on this innovative sensing approach were designed, fabricated, and investigated to assess their ability to measure various physical features, such as magnetic field, temperature, force, and volume, and to realize chemical sensors. In more detail, a sensitive patch of fiber was used in series with a multimodal waveguide where the SPR took place, to alter the mode profile of the light at the input of the waveguide itself. In fact, when the changes of the physical feature of interest acted on the sensitive patch, a variation of the incident angles of the light launched in the multimodal waveguide occurred, and, as a consequence, a shift in resonance wavelength took place. The proposed approach permitted the separation of the measurand interaction zone and the SPR zone. This meant that the SPR zone could be realized only with a buffer layer and a metallic film, thus optimizing the total thickness of the layers for the best sensitivity, regardless of the measurand type. The proposed review aims to summarize the capabilities of this innovative sensing approach to realize several types of sensors for different application fields, showing the high performances obtained by exploiting a simple production process and an easy experimental setup.
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http://dx.doi.org/10.3390/s23125662 | DOI Listing |
Expert Opin Ther Pat
September 2025
Dipartimento di Scienze per la Qualità della Vita, Alma Mater Studiorum - Università di Bologna, Rimini, Italy.
Introduction: Topoisomerase (topo) II inhibitors continue to represent a promising approach in anticancer therapy, although their clinical application is hampered by drug resistance and dose limiting toxicities.
Area Covered: We performed a critical analysis of patent literature from January 2016 to January 2025 on topo II inhibitors in oncology using the online databases Espacenet, Wipo, and Google patent.
Expert Opinion: Substantial progress in the development of novel topo II inhibitors through synthetic chemistry, natural product isolation, molecular modification, and in silico screening was recorded.
Expert Opin Drug Deliv
September 2025
Department of Pharmacology, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi, India.
Introduction: The potential of nanomedicine in alleviating different disorders is immense, but its clinical translation rate is severely debilitated, despite promising preclinical study outcomes. For therapeutically successful targeted delivery of nanomedicines, it is crucial to understand why well-designed nanomedicines often fail during clinical trials.
Areas Covered: This review comprehensively explores the multifactorial reasons behind the poor clinical success rate of nanomedicines, including pathophysiological complexity, limitations in statistical analysis, inadequate animal models, variability in the EPR effect, and manufacturing challenges.
Adv Mater
September 2025
School of Chemistry and Biochemistry, School of Materials Science and Engineering, Center for Organic Photonics and Electronics, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Molecular spin systems that can be chemically tuned, coherently controlled, and readily integrated within devices remain central to the realization of emerging quantum technologies. Organic high-spin materials are prime candidates owing to their similarity in electronic structure to leading solid-state defect-based systems, light element composition, and the potential for entanglement and qubit operations mediated through spin-spin exchange. However, the inherent instability of these species precludes their rational design, development, and application.
View Article and Find Full Text PDFAdv Child Dev Behav
September 2025
University of Virginia,Charlottesville, VA, USA. Electronic address:
This manuscript examines how home visiting by educators aligns with and informs culturally responsive and sustaining pedagogy (CR-SP) through the lens of developmental theory. Drawing on a synthesis of multiple qualitative studies, we analyze evidence of home visiting's influence on four dimensions of CR-SP: teachers' beliefs, dispositions, instructional practices, and integration of family and community knowledge. We find the strongest alignment between home visiting and teacher beliefs, including enhanced self-reflection, cultural competence, and asset-based thinking.
View Article and Find Full Text PDFJ Colloid Interface Sci
August 2025
School of Physical Science and Technology, Suzhou University of Science and Technology, Suzhou 215009, China; School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China. Electronic address:
Integration of the hydrogen evolution reaction (HER) and urea oxidation reaction (UOR) is a prospective strategy for energy-efficient hydrogen generation. However, developing highly effective dual functional catalysts for both HER and UOR is still challenging. Herein, two-dimensional rhodium‑nickel (RhNi) metallene with a wrinkled nanosheet structure is prepared by a feasible two-step hydrothermal approach, which provides numerous catalytically active centers and accelerates the charge transfer during the reaction.
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