Explicit analysis of , meterological and statistical hurdles in successful clinical translation of targeted nanomedicines and plausible remedial strategies.

Introduction: The potential of nanomedicine in alleviating different disorders is immense, but its clinical translation rate is severely debilitated, despite promising preclinical study outcomes. For therapeutically successful targeted delivery of nanomedicines, it is crucial to understand why well-designed nanomedicines often fail during clinical trials.

Areas Covered: This review comprehensively explores the multifactorial reasons behind the poor clinical success rate of nanomedicines, including pathophysiological complexity, limitations in statistical analysis, inadequate animal models, variability in the EPR effect, and manufacturing challenges.

Impact of atrial fibrillation in hospitalized patients undergoing endoscopic retrograde cholangiopancreatography: A nationwide analysis.

Background: Atrial fibrillation (AF) remains the most common cardiac arrhythmia. The safety of endoscopic retrograde cholangiopancreatography (ERCP) in patients with AF remains largely unknown.

Aim: To analyze the effect of AF on hospital outcomes in patients undergoing ERCP.

Sensitive Detection of Specific Volatile Organic Compounds by Functionalized Transition Metal Dichalcogenide Monolayers.

Timely detection of liver cirrhosis (LC) is critical for effective clinical management and improved patient outcomes. Among emerging diagnostic approaches, detection of volatile organic compounds (VOCs), related to LC, offers a noninvasive, rapid, and cost-effective alternative to conventional methods. In this work, we employed spin-polarized density functional theory (DFT) to systematically investigate the interaction of LC-related VOCs using transition-metal dichalcogenides (TMDs), specifically WX monolayers (X = S, Se).

Pediatric Diffuse High-Grade Gliomas: A Comprehensive Review Of Ad-vanced Methods Of Diagnosis And Treatment.

Glioblastoma multiforme (GBM) is an aggressive brain tumor, posing significant challenges in diagnosis and treatment, particularly in children. Understanding the pathogenesis, molecular biology, symptom presentation, and imaging features of GBM is vital for effective therapy. This review summarizes current knowledge on pediatric GBM, focusing on diagnosis and treatment.

Facilitating sustainable corporate growth in China: Examining the role of transition finance, green technology innovation, and ESG strategies in the path to sustainability.

This study investigates the impact of transition finance and green technology innovation on corporate level sustainability (measured via ESG scores) using a panel dataset of 23,660 listed firms in China from 2013 to 2022. The use of advanced statistical methods, such as cross-sectional dependence tests, slope heterogeneity tests, second-generation unit root tests, and Sys-GMM estimation, has made this study more robust. The findings indicate that transition finance and green technology innovation are key and decisive for corporate-level sustainability, as they both help to attract investment in decarbonization, sustainable projects, and activities or propose solutions aligned with pressing environmental challenges.

Explicating the transformative role of artificial intelligence in designing targeted nanomedicine.

Introduction: Artificial intelligence (AI) has emerged as a transformative force in nanomedicine, revolutionizing drug delivery, diagnostics, and personalized treatment. While nanomedicine offers precise targeted drug delivery and reduced toxic effects, its clinical translation is hindered by biological complexity, unpredictable in vivo behavior, and inefficient trial-and-error approaches.

Areas Covered: This review covers the application of AI and Machine Learning (ML) across the nanomedicine development pipeline, starting from drug and target identification to nanoparticle design, toxicity prediction, and personalized dosing.

Full characterization of partially coherent vector vortex beams via generalized Stokes parameters.

The generalized Stokes parameters (GSPs) for partially coherent vector vortex beams (PC-VVBs) are meticulously determined through a double-slit (DS) experiment, marking the first, to the best of our knowledge, measurement for polarization singular beams. GSPs provide a comprehensive characterization of PC-VVBs, encompassing the state of polarization (SoP), degree of polarization (DoP), and electromagnetic degree of coherence (EMDoC) information. It is demonstrated that the modulus and phase of GSPs provide information about the singularity index, polarity, and type of PC-VVB.

Association of FTO protein with hyperandrogenism metabolic disturbances in women with polycystic ovary syndrome.

Polycystic ovary syndrome (PCOS) is one of the commonest endocrinopathies in women characterized by hyperandrogenism, ovulatory dysfunction, and insulin resistance affecting 5-20% of reproductive-aged women worldwide. Recent studies have emphasized the role of the fat mass and obesity-associated (FTO) gene in the development of PCOS, specifically the rs9939609 A/T polymorphism, which is linked to an increased risk of PCOS. The study aimed to investigate the levels of FTO protein and its association with luteinizing hormone (LH), follicle-stimulating hormone (FSH) and anthropometric parameters in patients with PCOS compared to healthy controls.

Transforming pulmonary health care: the role of artificial intelligence in diagnosis and treatment.

Introduction: Respiratory diseases like pneumonia, asthma, and COPD are major global health concerns, significantly impacting morbidity and mortality rates worldwide.

Areas Covered: A selective search on PubMed, Google Scholar, and ScienceDirect (up to 2024) focused on AI in diagnosing and treating respiratory conditions like asthma, pneumonia, and COPD. Studies were chosen for their relevance to prediction models, AI-driven diagnostics, and personalized treatments.

Assessing the Combined Toxicity of Silver and Copper Nanoparticles in Rainbow Trout (Oncorhynchus mykiss) Fingerlings.

The growing use of silver (Ag) and copper (Cu) nanoparticles (NPs) for their antimicrobial properties has raised environmental health concerns due to their coexistence in aquatic ecosystems. This study assessed the combined physiological and molecular toxicity of AgNPs and CuNPs in rainbow trout (Oncorhynchus mykiss) exposed to sub-lethal concentrations of the NP mixture for 21 days. Fish were exposed to varying concentrations of co-exposure of AgNPs and CuNPs (T1 group 0.

Beyond the Bone Health: A Narrative Review Unveiling the Role of Bisphosphonates in Reducing the Risk of Myocardial Infarction.

Bisphosphonates, a class of anti-osteoporotic drugs, are known to inhibit bone resorption and reduce fracture risk. This review evaluates the evidence for their use and also aims to assess their potential benefits, safety, and effectiveness in reducing the risk of myocardial infarction. Bisphosphonates, in addition to their conventional role in bone health, reduce the accumulation of calcium within vascular walls.

An Overview of Unlocking the Power of Non-Coding RNAs in Revolutionizing Cancer Therapy.

Non-coding RNA (ncRNA) has been recognized to be an essential regulator of cellular processes and gene expression in cancer. The present study covers the various roles of ncRNAs, including circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and microRNAs (miR-NAs), that affect cancer properties. Oncogenesis, metastasis, and treatment resistance are all pro-cesses involving ncRNAs, which have tremendous potential as new therapeutic agents and tar-gets.

Gaps and Barriers to the Implementation of Antimicrobial Stewardship Programmes in Hospitals of Pakistan.

Antimicrobial-resistant bacteria are particularly prevalent in Southeast Asia, mainly due to inadequate infection prevention and control (IPC) and the widespread and uncontrolled use of antibiotics. Pakistan is the third largest low-middle-income country (LMIC) user of antibiotics. Antibiotic consumption increased by 65%, from 800 million to 1.

Silver nanoparticle toxicity in rainbow trout: insights into physiological and molecular responses.

Metallic nanoparticles, with their large surface area to volume ratio, are increasingly important in various life fields, but they can cause varying toxic effects on fish. This study investigates the toxicological effects of silver nanoparticles (AgNPs) on rainbow trout (), focusing on hematological, biochemical, antioxidant, and histopathological changes. Fish were exposed to varying concentrations of AgNPs (0.

Toxicological impact of copper nanoparticles on rainbow trout: hematological, biochemical, antioxidant, and histopathological responses with oxidative gene expression.

Copper nanoparticles (CuNPs) are increasingly used across various industries due to their catalytic, antimicrobial, and electrical properties. However, their potential toxicity in aquatic environments, particularly to non-target organisms like fish, remains poorly understood. This study investigated the effects of CuNP exposure on rainbow trout () by comprehensively evaluating hematological, biochemical, antioxidant, molecular, and histopathological parameters.

Nanotechnology in aquaculture: Transforming the future of food security.

In the face of growing global challenges in food security and increasing demand for sustainable protein sources, the aquaculture industry is undergoing a transformative shift through the integration of nanotechnology. This review paper explores the profound role of nanotechnology in aquaculture, addressing critical issues such as efficient feed utilization, disease management, and environmental sustainability. Nanomaterials are used to enhance nutritional content and digestibility of aquafeed, optimize fish growth and health, and improve disease prevention.

Aspergillus-mediated allergic airway inflammation is triggered by dendritic cell recognition of a defined spore morphotype.

Background: Exposure to fungi, especially Aspergillus fumigatus, can elicit potent allergic inflammation that triggers and worsens asthmatic disease. Dendritic cells (DCs) initiate allergic inflammatory responses to allergic stimuli. However, it is unclear if Af spores during isotropic growth (early spore swelling) can activate DCs to initiate allergic responses or if germination is required.

Home Food Delivery to Address Food Insecurity Following Hospital Discharge.

Nearly 1 in 5 families with children in the United States are food insecure. Hospitalization of a child can exacerbate food insecurity, both during the hospitalization and after discharge. Although some hospitals provide free or subsidized meals during hospitalization, few address food insecurity in the immediate posthospitalization period.

Involvement of macromolecules in 3D printing for wound healing management: A narrative review.

Wound healing comprises four overlapping stages involving complex biochemical and cellular processes. Any lapse in this procedure causes irregular healing, which generates clinical and financial burdens for the health system. Personalized treatment is preferred to overcome the limitations of classical as well as modern methods of wound healing.

Contemporary strategies in glioblastoma therapy: Recent developments and innovations.

Glioblastoma multiforme (GBM) represents one of the most prevailing and aggressive primary brain tumors among adults. Despite advances in therapeutic approaches, the complex microenvironment of GBM poses significant challenges in its optimal therapy, which are attributed to immune evasion, tumor repopulation by stem cells, and limited drug penetration across the blood-brain barrier (BBB). Nanotechnology has emerged as a promising avenue for GBM treatment, offering biosafety, sustained drug release, enhanced solubility, and improved BBB penetrability.

Clinical profile, treatment patterns and one-year outcome of heart failure patients admitted in tertiary care hospital of North India.

Introduction: Because of wide heterogeneity in the epidemiology of heart failure among different populations, it is imperative to establish population-specific databases.

Aims And Objectives: To describe the clinical profile, treatment patterns, and outcomes of heart failure patients admitted to our tertiary care hospital.

Material And Methods: The study was a prospective observational study conducted over two years at our tertiary care hospital.

Association of Non-High-Density Lipoprotein Cholesterol With Cardiometabolic Risk Factors in Patients With Hypothyroidism.

Introduction: Non-high-density lipoprotein cholesterol (non-HDL-C) levels can increase the cardiometabolic risk factors in patients with hypothyroidism, but the findings across studies have not been consistently conclusive. The aim of this study was to find the association between non-HDL-C and cardiometabolic risk factors in patients with hypothyroidism.

Material And Methods: In this case-control study, a total of 120 subjects among which 60 diagnosed hypothyroidism patients and 60 age-matched healthy controls were enrolled, aged 30-65 years.

Reinforcing the Unsettled Problem of Biological Weapon Convention in Pakistan: Reasons of Concern and Action.

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