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http://dx.doi.org/10.21037/apm-22-1124 | DOI Listing |
J Cell Mol Med
September 2025
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Diminished ovarian reserve (DOR) poses significant challenges in reproductive health, with emerging evidence implicating DNA damage repair pathways. While GADD45A is a critical regulator of DNA repair, cell cycle and apoptosis, its role in DOR pathogenesis remains unexplored. We employed transcriptome sequencing, qPCR and Western Blot analyses to compare GADD45A expression in granulosa cells (GCs) between DOR patients and controls.
View Article and Find Full Text PDFBiotechnol Lett
September 2025
Shandong Provincial Engineering Research Center for Precision Nutrition and Healthy Elderly Care, Qilu Medical University, 1678 Renmin West Road, Zibo, 255300, People's Republic of China.
Fatty acid synthase (FAS) is one of the most important enzymes in lipid biosynthesis, which can catalyze the reaction of acetyl-CoA and malonyl-CoA to produce fatty acids. However, the structure, function, and molecular mechanism of FAS regulating lipid synthesis in the fungus Mucor circinelloides are unclear. In the present study, two encoding fas genes in the high lipid-producing strain WJ11 and low lipid-producing strain CBS277.
View Article and Find Full Text PDFPlanta
September 2025
Smart Farm Research Center, Korea Institute of Science and Technology (KIST), Gangneung, Gangwon, 25451, Republic of Korea.
The regulation of photoperiod and light intensity significantly affected Agastache rugosa by enhancing growth, modifying flowering dynamics, and promoting the accumulation of key phenolic compounds. Agastache rugosa is a medicinal and aromatic plant valued for its bioactive compounds, which contribute to its application in the flavoring, perfume, and food industries. However, variability in the composition of the bioactive compounds poses challenges for its commercial utilization.
View Article and Find Full Text PDFJ Orthop Sci
September 2025
Hirosaki University Graduate School of Medicine, Department of Orthopedic Surgery, Hirosaki, Aomori, Japan.
Background: The concept of early-phase diffuse idiopathic skeletal hyperostosis (EDISH) was recently introduced and its prevalence at the thoracic spine level was revealed. Some cases of EDISH progress to diffuse idiopathic skeletal hyperostosis (DISH) in association with being overweight. The prevalence and distribution of EDISH in the whole spine and related factors are unclear.
View Article and Find Full Text PDFTrends Plant Sci
September 2025
Department of Plant and Environmental Sciences, Section of Transport Biology, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark. Electronic address:
Plants have developed sophisticated signaling mechanisms to adapt to environmental changes, and secreted peptides play crucial roles. Sulfated tyrosine (sTyr) peptides are important regulators of plant growth, nutrient uptake, defense responses, and seed development. This study delves into the evolution of sTyr peptides, their receptors, and the enzyme tyrosylprotein sulfotransferase (TPST) that is responsible for their activation.
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