Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The public perception of viruses has historically been negative. We are now at a stage where the development of tools to study viruses is at an all-time high, but society's perception of viruses is at an all-time low. The literature regarding viral interactions has been skewed towards negative (i.e., pathogenic) symbioses, whereas viral mutualisms remain relatively underexplored. Viral interactions with their hosts are complex and some non-pathogenic viruses could have potential benefits to society. However, viral research is seldom designed to identify viral mutualists, a gap that merits considering new experimental designs. Determining whether antagonisms, mutualisms, and commensalisms are equally common ecological strategies requires more balanced research efforts that characterize the full spectrum of viral interactions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184920 | PMC |
| http://dx.doi.org/10.1371/journal.pbio.3002109 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
P3IPs activate autophagy by disrupting the GAPC2-ATG3 interaction and target TuMV 6K2 for degradation.
New Phytol
September 2025
State Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Zhejiang Key Laboratory of Green Plant Protection, Institute of Plant Virology, Ningbo University, Ningbo, 315211, China.
Our previous work identified p3-interacting protein (P3IP) as a novel plant factor that interacts with rice stripe virus p3 protein and activates autophagy to mediate its degradation, thereby restricting infection. However, the mechanism of P3IP-mediated autophagy and the evolutionary conservation of its antiviral function remain unknown. This study demonstrates that two Arabidopsis thaliana homologs, AtP3IP and AtP3IPH (Arabidopsis P3IP homologs, AtP3IPs), similarly activate autophagy and confer resistance to turnip mosaic virus (TuMV).
View Article and Find Full Text PDFAntibacterial and antiviral properties of punicalagin (Review).
Med Int (Lond)
August 2025
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
Punicalagin, a polyphenolic compound extracted from pomegranate peel, has received increasing attention in recent years due to its antibacterial and antiviral properties. Punicalagin is capable of inhibiting bacterial growth at sub-inhibitory concentrations by affecting cell membrane formation, disrupting membrane integrity, altering cell permeability, affecting efflux pumps, interfering with quorum sensing and influencing virulence factors. Additionally, punicalagin inhibits viruses by modulating enzyme activity, interacting with viral surface proteins, affecting gene expression, blocking viral attachment, disrupting virus receptor interaction and inhibiting viral replication.
View Article and Find Full Text PDFInsights into LSD1 and quorum sensing inhibitory potential of phytoconstituents isolated from Thunb aerial parts.
RSC Adv
September 2025
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University Assiut 71526 Egypt
Thunb is endogenous to Southeast Asia and traditionally used for the treatment of bacterial and viral infections. Previous studies reported various pharmacological activities, including cytotoxic activity. The aim of this work was to identify phytoconstituents of the ethanolic extract of aerial parts using extensive 1D- and 2D-NMR analysis and HR-MS.
View Article and Find Full Text PDFDeficient of glycosylation site in the envelop protein attenuated Zika virus replication in mosquito cells.
Front Microbiol
August 2025
College of Life Sciences, Hebei University, Baoding, China.
Introduction: The Zika virus (ZIKV) envelope (E) protein is critical for viral replication and host interactions. Although glycosylation of the E protein is known to influence viral infectivity and immune evasion, the specific functional roles of E protein glycosylation in ZIKV infectivity in mosquito cells remain unclear.
Methods: In this study, we generated a deglycosylation mutant ZIKV with a T156I substitution in the E protein and investigated its effects on viral replication and viral-host interactions in mosquito C6/36 cells.
Protocol to produce a systematic Arenavirus and Hantavirus host-pathogen database: Project ArHa.
Wellcome Open Res
August 2025
Paul G. Allen School for Global Health, Washington State University, Pullman, Washington, USA.
Arenaviruses and Hantaviruses, primarily hosted by rodents and shrews, represent significant public health threats due to their potential for zoonotic spillover into human populations. Despite their global distribution, the full impact of these viruses on human health remains poorly understood, particularly in regions like Africa, where data is sparse. Both virus families continue to emerge, with pathogen evolution and spillover driven by anthropogenic factors such as land use change, climate change, and biodiversity loss.
View Article and Find Full Text PDF