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http://dx.doi.org/10.1111/tid.14067 | DOI Listing |
Vet Sci
August 2025
College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
is responsible for the disease toxoplasmosis and has the broadest host range among apicomplexan parasites, as it infects virtually all warm-blooded vertebrates. Toxoplasmosis is a zoonotic and emerging public health concern with considerable morbidity and mortality, especially in the developing world, affecting approximately one-third of the world's human population. Clinical presentation varies among species, and the infection establishes lifelong chronicity in hosts.
View Article and Find Full Text PDFMicrobiol Spectr
August 2025
Laboratório de Biologia Estrutural, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil.
Unlabelled: Toxoplasmosis is caused by infection with and is one of the most prevalent food-borne parasitic disease worldwide. disseminates through the host organism and forms a latency-specific structure called bradyzoite cysts, found primarily in muscle and neuronal cells. In mice, Toxoplasma leads to sustained brain microvascular abnormalities, including capillary rarefaction, microglial activation, and blood-brain barrier (BBB) breakdown, resulting in synaptic and neuronal loss, behavioral and cognitive damages.
View Article and Find Full Text PDFPLoS Negl Trop Dis
July 2025
Department of Biochemistry, Cinvestav, Mexico.
Toxoplasma gondii is a highly adaptable intracellular parasite capable of infecting a wide range of warm-blooded animals, including humans. Following the ingestion of cysts and oocysts, the parasites rapidly emerge and transmigrate through the bloodstream, initiating a complex infection process. Despite reports on the parasite's dissemination, the mechanisms behind its migration remain unclear.
View Article and Find Full Text PDFJ Proteomics
July 2025
Departamento de Bioquímica, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav), Av. IPN No. 2508, Ciudad de Mexico, C.P. 07360, Mexico. Electronic address:
The Toxoplasma gondii cytoskeleton is a highly organized structure essential for parasite motility, replication, and host cell invasion. To identify its components, a highly enriched fraction of tachyzoite cytoskeletons was obtained and quantitatively analyzed by mass spectrometry. We identified 623 proteins classified into 18 functional groups, including 30 IMC proteins, 34 cytoskeleton proteins, and 14 uncharacterized proteins.
View Article and Find Full Text PDFBraz J Microbiol
September 2025
Departamento de Medicina Veterinária, Laboratório de Doenças Parasitárias, Programa de Pós-Graduação em Medicina Veterinária, Universidade Federal de Santa Maria, Rio Grande do Sul, Santa Maria, Brasil.
Non-human primates (NHP) can serve as intermediate or accidental hosts for sarcocystid pathogens, which vary in pathogenicity and relevance to wildlife and public health. This study aimed to detect DNA from the members of the Sarcocystidae family in tissue samples from 22 captive monkeys that died between 2019 and 2023 in a zoo located in southern Brazil. A total of 84 samples were analyzed using nested PCR, restriction fragment length polymorphism (RFLP), and specific primers to identify Sarcocystis spp.
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