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Article Abstract
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542838 | PMC |
| http://dx.doi.org/10.3324/haematol.2022.282220 | DOI Listing |
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Killer cell immunoglobulin-like receptor (KIR) alleles suggested to be associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
Brain Behav Immun
August 2025
Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway; Department of Immunology, University of Oslo and Oslo University Hospital, Oslo, Norway. Electronic address:
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease with unknown cause. Involvement of infection and immune dysregulation has been suggested, including changes in immune cell subsets and abnormal functions of natural killer (NK) cells. The regulatory NK cell receptors, killer cell immunoglobulin-like receptors (KIR) have previously been investigated in small cohorts of ME/CFS patients with conflicting results regarding gene content.
View Article and Find Full Text PDFTumor gene expression signatures associated with outcome in large B-cell lymphoma treated with CD19-directed CAR T-cell therapy (axicabtagene ciloleucel).
Front Oncol
February 2025
Kite, a Gilead Company, Santa Monica, CA, United States.
Introduction: CAR T cell therapy provided transformative outcomes for patients with B-cell lymphoma; however, a large fraction of patients remains at risk for relapse, underlying the need to uncover mechanisms of resistance and predictive biomarkers. Herein, we leveraged the ZUMA-7 phase III randomized trial of relapsed/refractory large B-cell lymphoma (LBCL) patients treated with axicabtagene ciloleucel (axi-cel; CD19-targeting CAR T cells) to discover tumor gene expression signatures (GES) associated with outcome.
Methods: With tumor transcriptomics from 134 axi-cel patients, we employed multivariate penalized Cox models analyzing event-free survival (EFS), progression-free survival (PFS), and duration of response (DOR).
KIR3DL2 may represent a novel therapeutic target in aggressive systemic peripheral T-cell lymphoma.
Haematologica
October 2023
Paris-Est Créteil University (UPEC), Institut Mondor de Recherche Biomédicale (IMRB), INSERM U955, F-94010, Créteil, France; Henri Mondor hospital, AP-HP, Department of Pathology, F-94010, Créteil.
MHC Class I Ligands of Rhesus Macaque Killer Cell Ig-like Receptors.
J Immunol
June 2023
Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI.
Article Synopsis
- - The study focuses on identifying the interactions between rhesus macaque killer cell Ig-like receptors (KIRs) and MHC class I molecules, which is crucial for understanding natural killer (NK) cell biology in these primates as they serve as important animal models for various fields.
- - Researchers tested rhesus macaque KIRs against different MHC class I alleles and discovered 12 KIRs with previously unknown specificities, categorizing their interactions primarily into three groups: those that bind to Mamu-Bw4, Mamu-A-related molecules, and Mamu-A1*012:01.
- - Most KIRs interacting with Mamu-Bw4 were inhibitory, while those binding to Mamu
Analysis of KIR gene variants in The Cancer Genome Atlas and UK Biobank using KIRCLE.
BMC Biol
August 2022
Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Background: Natural killer (NK) cells represent a critical component of the innate immune system's response against cancer and viral infections, among other diseases. To distinguish healthy host cells from infected or tumor cells, killer immunoglobulin receptors (KIR) on NK cells bind and recognize Human Leukocyte Antigen (HLA) complexes on their target cells. However, NK cells exhibit great diversity in their mechanism of activation, and the outcomes of their activation are not yet understood fully.
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