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Background: There are numerous cartilaginous grafts that can be used in rhinoplasty, depending on the specific needs of the patient. These include spreader grafts, dorsal onlay, tip grafts, septal extension, and columellar struts grafts, among others.
Objective: The aim of this study is to demonstrate use of the hammer graft in rhinoplasty; this technique can be used to improve dorsal support, tip projection, and tip rotation using a single cartilage graft.
Materials And Methods: This novel graft was applied in 18 patients who underwent rhinoplasty. In revision patients, hammer graft was harvested from costal cartilage and in primary cases from septum cartilage. They were followed in average 12 months (between 6 and 18 months).
Result: Three of these patients were revision cases and 15 were primary cases. In revision patients, hammer graft was harvested from costal cartilage and in primary cases from septal cartilage. The targeted results were achieved to a large extent in all patients. All patients had satisfactory esthetic results.
Conclusion: The hammer graft as a single and stable graft useful support for the dorsal part, caudal part and extension part of the septum to be used in primary and revision rhinoplasty.
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http://dx.doi.org/10.1016/j.amjoto.2023.103901 | DOI Listing |
bioRxiv
August 2025
Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
Induced pluripotent stem cell (iPSC)-derived natural killer (iNK) cells offer a promising platform for off-the-shelf immunotherapy against hematological malignancies. NK cell function is dynamically regulated through education driven by inhibitory receptors, including CD94/NKG2A and killer cell immunoglobulin-like receptors (KIR). However, the acquisition of inhibitory receptors in iNK cells and their role during differentiation and education remains poorly defined.
View Article and Find Full Text PDFOphthalmologie
August 2025
Universitätsklinikum Halle, Klinik und Poliklinik für Augenheilkunde, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle (Saale), Deutschland.
Background: In recent years, the Descemet membrane endothelial keratoplasty (DMEK) has become the standard transplantation procedure for endothelial corneal diseases due to faster visual recovery and lower graft rejection rates compared to penetrating keratoplasty (pKPL). Endothelial corneal decompensation after pKPL is also a possible indication for DMEK. The question is which intraoperative and postoperative aspects need to be considered.
View Article and Find Full Text PDFJ Clin Invest
August 2025
Department of Immunology and.
Type 1 diabetes is characterized by the autoimmune destruction of pancreatic β cells, resulting in permanent loss of glucose homeostasis. Islet transplantation is a promising potential cure that remains hindered by immune rejection. We previously showed that ST8Sia6 expression on tumors reduced immune surveillance and hypothesized that this sialyltransferase could protect β cells from autoimmune destruction.
View Article and Find Full Text PDFJ Thorac Cardiovasc Surg
July 2025
Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Mass. Electronic address:
Objectives: To characterize longitudinal changes in lateral tunnel (LT) and extracardiac conduit (EC) Fontan pathway geometry and flow dynamics and to investigate whether these parameters mediate differences in outcomes by Fontan type.
Methods: Patients who underwent Fontan at our institution between 2000 and 2017 and were evaluated with post-Fontan computed tomography (CT)/magnetic resonance imaging (MRI) were reviewed retrospectively. Three-dimensional segmentations of the Fontan pathways were generated.
Sci Immunol
July 2025
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
CD8 T cells are classically defined by cytotoxic activity, but it has remained unclear whether cytotoxic programs are compartmentalized across tissues and memory subsets. Here, we established a human organ donor cohort and found that expression of conventional cytotoxic molecules-granulysin, perforin, and granzyme B-was most prominent among circulating memory CD8 T cells and decreased progressively with tissue residency, inversely mirroring the expression of CD69 and CD103. Other cytotoxic molecules, including granzymes A, H, K, and M, were variably expressed across tissues, and memory CD8 T cells targeting persistent viruses expressed multiple granzymes coordinately.
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