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Persistent sciatic artery (PSA) is a rare congenital anomaly considered an embryologic remnant of the internal iliac artery. Traditionally, the classification systems categorized PSA based on the completeness of PSA and superficial femoral artery (SFA) alongside the origin of PSA. The most common class has been known as type 2a in Pillet-Gauffre classification, meaning complete PSA with incomplete SFA. The mainstay of these patients with limb ischemia has been surgical bypass alongside excision or ligation of PSA aneurysm if present. However, the current PSA classification system does not account for collateral blood flow. Herein, we described two cases of type 2a PSA with distal embolization and explored therapeutic choices for PSA based on collateral presence. The first patient was treated with thromboembolectomy and patch angioplasty, and the second with conservative management. Despite distal embolization in both patients, bypass surgery was avoided, and distal circulation was maintained collaterals from deep and superficial femoral arteries without increased risk of recurrent embolization. Thus, carefully examining collateral circulation and customized strategy is essential for managing PSA.
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http://dx.doi.org/10.3389/fsurg.2023.1159463 | DOI Listing |
Clin Teach
October 2025
Warwick Medical School, Coventry, UK.
Background: Prescribing is a high-stakes clinical task where newly qualified doctors frequently report low confidence, with national data highlighting persistent error rates. Medical schools face logistical and staffing barriers in delivering high-quality, simulation-based prescribing education. Peer-led, interprofessional teaching, particularly by pharmacists, may offer a scalable solution in this context.
View Article and Find Full Text PDFProstate
September 2025
Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada.
Background: The USPSTF recommendation against PSA screening (RAPS) in 2012 resulted in unfavorable changes in prostate cancer (PCa) outcomes. However, the effect on cancer-specific mortality (CSM) in localized PCa has not been assessed.
Methods: Within the Surveillance, Epidemiology, and End Results database (2004-2021), we identified patients treated with radiotherapy (RT) or radical prostatectomy (RP) for localized PCa.
Rheumatol Int
September 2025
Division of Rheumatology and Immunology, Department of PMR, , Sakarya University School of Medicine, Sakarya, Turkey.
To identify clinical and demographic predictors associated with the timing of transition from psoriasis (PsO) to psoriatic arthritis (PsA), and to compare the characteristics of patients with concurrent PsO-PsA onset versus those with prolonged transition. A multi-center, observational study was conducted using data from the Turkish League Against Rheumatism (TLAR) network including PsA patients fulfilling CASPAR criteria. Patients were categorized into two groups: Group 1 (concurrent PsO and PsA onset within ± 1 year) and Group 2 (prolonged transition to PsA, > 1 year after PsO).
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Health Statistics, School of Public Health, Shandong Second Medical University, Weifang, Shandong, China.
Both psoriasis and autoimmune thyroid diseases are characterized by chronic inflammation. The previous studies indicated a potential association between psoriasis and autoimmune thyroid diseases. However, the direction and nature of these relationships remain unclear.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Jingjiang People's Hospital Affiliated to Yangzhou University, Taizhou, Jiangsu, China.
Previous epidemiological research has shown that immune cells have a significant impact on the progression and development of psoriatic arthritis (PsA). However, the causal relationship between immune cell characteristics and PsA remains uncertain. A bidirectional 2-sample Mendelian randomization analysis was conducted, using data from publicly available genome-wide association studies.
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