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Metal-based drugs have attracted growing interest in biomedicine [...].
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http://dx.doi.org/10.3390/ijms24087289 | DOI Listing |
RSC Med Chem
July 2025
Instituto de Química, Universidad Nacional Autónoma de México Circuito Exterior Ciudad de México CP 04510 Mexico +52 5556162217 +52 5556224514.
Metal-based compounds are excellent alternative drugs for oncological treatment and research. The successful use of cisplatin and its derivatives clearly exemplifies the important role of such compounds in cancer therapy. However, the low selectivity, side effects, and resistance associated with this drug have led to the search for new strategies to overcome these limitations.
View Article and Find Full Text PDFRSC Adv
August 2025
University of Technology Owerri, P.M.B 1526 Owerri Imo State Nigeria.
The global rise of antimicrobial resistance has intensified the search for novel therapeutic agents that act through non-conventional mechanisms. Gallium-based nanoparticles (GaNPs) represent a promising yet underexplored class of metal-based antimicrobials. Owing to their unique ability to mimic iron(iii), GaNPs disrupt key bacterial metabolic processes, particularly those dependent on iron acquisition and utilization.
View Article and Find Full Text PDFMicrobiology (Reading)
September 2025
Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.
The opportunistic pathogens and are often found together causing persistent infections where they exhibit complex interactions that affect their virulence and resistance to treatment. We sought to clarify how interactions between these organisms affect their resistance to the antimicrobial metal silver (AgNO). As previous work showed that cell-free supernatant from enhances the resistance of we aimed to identify the exact factor(s) responsible for this increase.
View Article and Find Full Text PDFSmall Methods
September 2025
Institute for Materials Discovery, University College London, London, WC1E 7JE, UK.
The development of planar on-chip micro-batteries with high-capacity electrodes and environmentally friendly and stable architectures is critical for powering the next generation of miniaturized system-on-chip smart devices. However, realizing highly stable micro-batteries remains a major challenge due to complex fabrication processes, electrode degradation during cycling, and the uncontrolled growth of dendrites in metal-based anodes within the confined spaces between electrodes. To address these issues, this study presents an approach that incorporates a 3D porous nickel (Ni) scaffold at the metal anode, offering improved micro-anode stability compared to conventional planar zinc and 3D porous zinc (Zn) scaffolds.
View Article and Find Full Text PDFInt J Mol Sci
August 2025
Organic Chemistry Laboratory, University of Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, Germany.
Human fungal infections comprise systemic mycoses as well as various skin diseases. Rising case numbers along with inefficient therapies and the appearance of drug-resistant strains unleashed a considerable health problem over the last years. Thus, the identification and development of new antifungal drugs is mandatory, which can include the design of new antifungals, or, more time saving, the repurposing of known drugs already applied for the therapy of other human diseases.
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