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A clock distribution network (CDN) is a ubiquitous on-chip element that provides synchronized clock signals to all different circuit blocks in the chip. To maximize the chip performance, today's CDN demands lower jitter, skew, and heat dissipation. Conventionally, on-chip clock signals have been distributed in the electric voltage domain, resulting in increased jitter, skew, and heat dissipation due to clock drivers. While low-jitter optical pulses have been locally injected in the chip, research on effective distribution of such high-quality clock signals has been relatively sparse. Here, we demonstrate femtosecond-precision distribution of electronic clocks using driver-less CDNs injected by photocurrent pulses extracted from an optical frequency comb source. Femtosecond-level on-chip jitter and skew can be achieved for gigahertz-rate clocking of CMOS chips by combining ultralow comb-jitter, multiple driver-less metal-meshes, and active skew control. This work shows the potential of optical frequency combs for distributing high-quality clock signals inside high-performance integrated circuits, including 3D integrated circuits.
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http://dx.doi.org/10.1038/s41467-023-38122-3 | DOI Listing |
Physiol Plant
September 2025
Agriculture and Agri-Food Canada, Saskatoon Research and Development Centre, Saskatoon, Saskatchewan, Canada.
Dormancy release and germination of the seed are two separate, but continuous phases controlled by both external (e.g., light and temperature) and internal (e.
View Article and Find Full Text PDFFungal Biol
October 2025
Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Electronic address:
In many model organisms, the circadian system has been proposed to comprise multiple oscillators that interact to promote accuracy of the clock as well as intricacies of rhythmic outputs. In Neurospora crassa, the circadian transcriptional/translational loop comprising of the FRQ (Frequency) and WCC (White Collar Complex) proteins has been instrumental in explaining many attributes of the clock including entrainment and rhythms in development and gene expression; in addition, some non-circadian oscillations can be unmasked when the FRQ-WCC feedback loop is eliminated. These rhythms have often lost defining circadian characteristics and are potentially controlled by other oscillators, termed FRQ-less oscillators (FLOs) in Neurospora.
View Article and Find Full Text PDFMol Nutr Food Res
September 2025
Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China.
Current research indicates that insulin secretion deficiency in β-cells contributes to Type 2 diabetes mellitus (T2DM), which is associated with neuropeptide Y receptor (Npy1r) overexpression from neuropeptide Y (NPY) system dysregulation. To date, limited literature has explored nobiletin (NOB) as a circadian modulator for restoring β-cell function through Npy1r regulation. This study investigates NOB's stimulatory effects on insulin secretion via Npy1r and clock-modulatory signaling to elucidate its underlying mechanism.
View Article and Find Full Text PDFmedRxiv
August 2025
Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with a largely unknown duration and pathophysiology of the pre-diagnostic phase, especially for the common non-monogenic form.
Methods: We leveraged the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort with up to 30 years of follow-up to identify incident ALS cases across five European countries. Pre-diagnostic plasma samples from initially healthy participants underwent high-throughput proteomic profiling (7,285 protein markers, SomaScan).
PLoS One
September 2025
Department of Physical and Chemical Sciences, University of Toronto, Mississauga, Ontario, Canada.
Single-cell fluorescence characterization has gained much attention for studying the dynamics of individual cells in human diseases such as cancer. Despite the abundance of literature on quantitative fluorescence microscopy and its advantages in measuring cell-to-cell variation and spatial variation over other high-throughput instruments, there lacks a concise model that one can follow to maximize the quality of images. Here, we used the signal-to-noise ratio (SNR) model to verify marketed camera parameters and optimize microscope settings to maximize SNR for quantitative single cell fluorescence microscopy (QSFM).
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