Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Modern medicine requires intensive research to find new diagnostic and therapeutic solutions. Recently, upconverting nanoparticles (UCNPs) doped with lanthanide ions have attracted significant attention. The efficient internalization of UCNPs by cells was confirmed, and their precise cellular localization was determined by electron microscopy and confocal studies. UCNPs colocalized only with specific organelles, such as early endosomes, late endosomes and lysosomes. Furthermore, experiments with chemical inhibitors confirmed the involvement of endocytosis in UCNPs internalization and helped select several mechanisms involved in internalization. Exposure to selected UCNPs concentrations did not show significant cytotoxicity, induction of oxidative stress or ultrastructural changes in cells. This study suggests that UCNPs offer new diagnostic options for biomedical infrared imaging.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/nnm-2022-0320 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hydrophilicity-Driven Modulation of Amyloid-β(1-40) Fibrillation by Engineered Nanomaterials.
ACS Appl Mater Interfaces
September 2025
State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, 116024 Dalian, China.
Amyloid-β (Aβ) fibrillation is a spontaneous, thermodynamic process governed by nucleation and elongation. While many studies have explored the ability of engineered nanomaterials (ENMs) to modulate Aβ fibrillation, such as inhibitors, promoters, and dual-modulators, the key physicochemical property of ENMs that determines this behavior remains unclear. In this study, we developed a comprehensive library of ENMs with well-controlled physicochemical properties, including surface charges, morphologies, and hydrophilicity, to systematically investigate their effects on Aβ40 fibrillation.
View Article and Find Full Text PDFEvaluation of CoFeO-L-Au (L: Citrate, Glycine) as Superparamagnetic-Plasmonic Nanocomposites for Enhanced Cytotoxic Activity Towards Oncogenic (A549) Cells.
Int J Mol Sci
August 2025
Departamento de Química, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad #940, Aguascalientes C.P. 20100, Aguascalientes, Mexico.
We investigated the influence of gold deposition on the magnetic behavior, biocompatibility, and bioactivity of CoFeO (MCF) nanomaterials (NMs) functionalized with sodium citrate (Cit) or glycine (Gly). The resulting multifunctional plasmonic nanostructured materials (MCF-Au-L, where L is Cit, Gly) exhibit superparamagnetic behavior with magnetic saturation of 59 emu/g, 55 emu/g, and 60 emu/g, and blocking temperatures of 259 K, 311 K, and 322 K for pristine MCF, MCF-Au-Gly, and MCF-Au-Cit, respectively. The MCF NMs exhibit a small uniform size (with a mean size of 7.
View Article and Find Full Text PDFDual-Terminal Molecular Strategy for Robust and Reversible Supramolecular Adhesion.
Adv Sci (Weinh)
August 2025
State Key Laboratory of Metastable Materials Science and Technology, Nano-bio-technology Key Lab of Hebei Province, Applying Chemistry Key Lab of Hebei Province, Yanshan University, Qinhuangdao, 066004, P. R. China.
Achieving strong yet reversible adhesion via minimalist molecular design remains a critical challenge for next-generation supramolecular materials. Here, a dual-end modular adhesion strategy is presented based on a small organic molecule incorporating carboxylic acid and triphenylphosphonium terminals linked by a flexible alkyl spacer. This design enables synergistic noncovalent interactions-including hydrogen bonding, dipole-dipole interactions, and electrostatic forces-to construct a thermally reconfigurable supramolecular network.
View Article and Find Full Text PDFSnSe quantum dot-albumin Interface: Interaction study of the serum albumin protein with SnSe quantum dot for the analysis of kinetics and energy transfer process with associated unfolding of protein.
Int J Biol Macromol
September 2025
Department of Physics, Government General Degree College Gopiballavpur-II, Jhargram 721517, West Bengal, India. Electronic address:
The dynamics of the in-situ interaction of SnSe QDs with model albumin protein (ALB) of BSA showed that the surface binding occurs for long time (131 min) and the unfolding of protein occurs for short time (33 min). Corona formation have been observed through HRTEM images. The emission quenching showed tertiary deformation of the ALB structure with negative cooperative binding with binding constant, n = 0.
View Article and Find Full Text PDFDistinct structural interactions of polyadenine and polythymine on gold nanoparticles: from single strands to duplexes.
Chem Sci
July 2025
CIC biomaGUNE, Basque Research and Technology Alliance (BRTA) 20014 Donostia-San Sebastián Spain
Motivated by potential applications in fields such as medicine or materials science, various methodologies have been developed for the preparation of so-called spherical nucleic acids, based on oligonucleotides and metal nanoparticles. Despite optimization through various parameters such as loading efficiency or nanoconjugate stability, much remains to be known regarding the actual conformations of oligonucleotides and their interactions with the nanoparticle surface. We employed a combination of spectroscopic techniques and liquid transmission electron microscopy to analyze the interactions and conformations adopted by polyAdenine (polyA) and polyThymine (polyT) chains in contact with gold nanoparticles (AuNPs).
View Article and Find Full Text PDF