98%
921
2 minutes
20
In this exploratory analysis, we assessed whether nutrition modified the association between prenatal exposure to tobacco and childhood cognition/behavior among 366 Colorado-based mothers and their offspring (born ≥ 37 weeks with birthweights ≥ 2500 g). Interaction by folate (≥ 1074 µg/day) and breastfeeding (≥ 5 months) was assessed by including a product term with cotinine (≥ limit of detection [LOD]) in regression models for NIH Toolbox and Child Behavior Checklist T-scores. Main effects were observed between cotinine ≥ LOD and inhibitory control (- 3.2; 95% CI: - 6.8, 0.3), folate < 1074 µg/day and anxious/depressed symptoms (1.1; 95% CI: 0.1, 2.1), and breastfeeding < 5 months and receptive language (- 4.3; 95% CI: - 8.5, - 0.02), though these findings would not survive Bonferroni correction. Breastfeeding modified the tobacco-behavior associations. Sleep (3.8; 95% CI: 0.5, 7.1; interaction p-value = 0.02), depressive (4.6; 95% CI: 1.0, 8.2; interaction p-value = 0.01) and total problems (5.8; 95% CI: - 0.7, 12.4; interaction p-value = 0.09) were observed among tobacco-exposed offspring who breastfed > 5 months, but not for shorter durations. Our findings support the need for smoking cessation campaigns throughout pregnancy and throughout the postpartum period breastfeeding to reduce neurobehavioral risks in the offspring.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828757 | PMC |
http://dx.doi.org/10.1007/s10578-023-01524-x | DOI Listing |
J Affect Disord
September 2025
Department of emergency, West China Second University Hospital, Sichuan University, Chengdu, 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, 610041, China; Department of Emergency, Chengdu Hi-Tech Zone Ho
Background: Studies examining the association between maternal antibiotic use during pregnancy and the risk of childhood attention-deficit/hyperactivity disorder (ADHD) have yielded inconsistent results. This meta-analysis synthesizes available evidence to establish a more comprehensive understanding of this association.
Methods: Observational studies published through October 2, 2024, were systematically searched from Cochrane Library, EMBASE, Web of Science, and PubMed databases.
Mol Cell Endocrinol
September 2025
Department of Epidemiology, University of Michigan, Ann Arbor, USA. Electronic address:
Steroid hormones are integral to pregnancy and fetal development, regulating processes such as metabolism, inflammation, and immune responses. Excessive prenatal steroid exposure, through lifestyle choices or environmental chemicals, can lead to metabolic dysfunctions in offspring. The research focuses on how exposure to testosterone (T) and bisphenol A (BPA) affects the liver's DNA methylome, a key component of the epigenome influencing long-term health.
View Article and Find Full Text PDFEnviron Int
August 2025
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina, Chapel Hill, NC, USA; Institute for Environmental Health Solutions, Gillings School of Global Public Health, The University of North Carolina, Chapel Hill, NC, USA. Electr
Background: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may adversely impact child neurodevelopment; however, epidemiologic findings remain inconclusive because of small sample sizes, limited exposure variability, and differing neurodevelopmental measures. We aimed to investigate the relationship between prenatal PFAS exposure and child behavior.
Methods: We pooled data from nine study sites in the nationwide Environmental influences on Child Health Outcomes (ECHO) Cohort.
Paediatr Perinat Epidemiol
September 2025
Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine, Houston, Texas, USA.
Background: The few studies that have examined the impact of PM on reduced birthweight across different percentiles of the conditional birthweight distribution have produced equivocal findings, and only two assessed whether these associations varied by race/ethnicity or by racial/ethnic composition of the neighbourhood where mothers lived.
Objective: We evaluated racial/ethnic differences in the association between prenatal PM exposure and birthweight across the birthweight distribution in a retrospective cohort study comprising 102,986 full-term singleton births in Harris County, Texas (2019-2020).
Methods: Census tract-level daily PM concentrations were estimated using 'XGBoost-IDW Synthesis', and averaged exposures over pregnancy.
Am J Physiol Heart Circ Physiol
September 2025
Department of Pediatrics, Washington University, St. Louis, Missouri.
Excess testosterone (T) exposure from early to mid-gestation (days 30-90) leads to sexually dimorphic adverse cardiac left ventricular (LV) programming at fetal day 90 (term 147 days). Whether this sexually dimorphic impact is a direct effect of T or reprogramming that persists beyond early fetal life is unknown. We hypothesized that adverse sex-specific cardiac outcomes seen in early fetal life will persist in late gestational fetuses.
View Article and Find Full Text PDF