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Direct policy search (DPS) is a method for identifying optimal policies (i.e., rules) for managing a system in response to changing conditions. In this article, we introduce a new adaptive way to incorporate learning into DPS. The standard DPS approach identifies "robust" policies by optimizing their average performance over a large ensemble of future states of the world (SOW). Our approach exploits information gained over time, updating prior beliefs about the kind of SOW being experienced. We first run the standard DPS approach multiple times, but with varying sets of weights applied to the SOWs when calculating average performance. Adaptive "metapolicies" then further improve performance by specifying how control of the system should switch between policies identified using different weight sets, depending on our updated beliefs about the relative likelihood of being in certain SOWs. We outline the general method and illustrate it using a case study of efficient dike heightening that simultaneously minimizes protection system costs and flood damage resulting from rising sea levels and storm surge. The solutions identified by our adaptive algorithm dominate the standard DPS on these two objectives, with an average marginal damage reduction of 35.1% for policies with similar costs; improvements are largest in SOWs with relatively lower sea level rise. We also evaluate how performance varies under different ways of implementing the algorithm, such as changing the frequency with which beliefs are updated.
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http://dx.doi.org/10.1111/risa.14136 | DOI Listing |
Microbiol Spectr
September 2025
Department of Biological Sciences, Molecular and Computational Biology Section, University of Southern California, Los Angeles, California, USA.
expresses three ferritins that store acquired iron by oxidizing soluble Fe(II) to insoluble Fe(III), which can accumulate and later be utilized in cellular processes. Although bacterioferritin (Bfr) and ferritin (FtnA) sequester more Fe(III) atoms per multimeric complex, the abundance of the DNA-binding protein from starved cells (Dps), coupled with its preference for hydrogen peroxide as an oxidant in its ferroxidase activity, makes it a fundamental component in iron homeostasis and long-term stationary phase (LTSP) survival. To investigate the temporal role and mechanisms of action of Dps in parallel with the other ferritins, growth yield, survival, competitive fitness, and siderophore assays were performed under different conditions of iron availability.
View Article and Find Full Text PDFBMC Oral Health
August 2025
Dental Biomaterials Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Background: Various medicaments have been utilized as an aid for wound healing following vital pulp treatment. Many of them are synthetic in origin and have disadvantages as limited amount of cytotoxicity and great expense. Hence, to tackle these drawbacks, naturally derived blended scaffolds have been employed in renovative dental field.
View Article and Find Full Text PDFEndocrine
August 2025
Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar (Mohali), Punjab, India.
Background: Sodium-glucose cotransporter 2 inhibitors (SGLT-2is) manage type 2 diabetes mellitus (T2DM) via increased urinary glucose excretion; however, their use is associated with an elevated risk of genitourinary infections. This study aims to evaluate this risk by synthesizing evidence from randomized controlled trials (RCTs) and characterizing clinical features using data from the FDA Adverse Event Reporting System (FAERS).
Methods: In this systematic review and meta-analysis, we searched PubMed and Embase up to June 2024 for RCTs reporting genital mycotic infection (GMI) and urinary tract infection (UTI) events associated with SGLT-2is.
Biol Trace Elem Res
August 2025
Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, 21515, Egypt.
Exposure to heavy metals and unbalanced diets poses significant global health concerns. This study investigated the neurotoxic effect of chronic lead acetate and high-fat diet (Pb/HFD) co-exposure in rats and the neuroprotective potential of 10-hydroxydecanoic acid (HDA) and zinc oxide nanoparticles (ZnO-NPs). Rats were allocated into naive, HDA, ZnO-NPs, MIX (HDA/ZnO-NPs), Pb/HFD, Pb/HFD + HDA, Pb/HFD + ZnO-NPs, and Pb/HFD + MIX, with 10 rats per group.
View Article and Find Full Text PDFProc SPIE Int Soc Opt Eng
February 2025
Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Diffusion models have demonstrated a powerful capability to generate a diversity of high quality images based on a training distribution. Recently, such diffusion models have been used in CT restoration and reconstruction via conditional generation. Diffusion posterior sampling (DPS) is a conditional generation method with several advantages, including unsupervised learning of the prior distribution and plug-and-play capabilities with different forward models to encompass different acquisition methods, protocols, etc.
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