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The evolutionary multitask optimization (EMTO) algorithm is a promising approach to solve many-task optimization problems (MaTOPs), in which similarity measurement and knowledge transfer (KT) are two key issues. Many existing EMTO algorithms estimate the similarity of population distribution to select a set of similar tasks and then perform KT by simply mixing individuals among the selected tasks. However, these methods may be less effective when the global optima of the tasks greatly differ from each other. Therefore, this article proposes to consider a new kind of similarity, namely, shift invariance, between tasks. The shift invariance is defined that the two tasks are similar after linear shift transformation on both the search space and the objective space. To identify and utilize the shift invariance between tasks, a two-stage transferable adaptive differential evolution (TRADE) algorithm is proposed. In the first evolution stage, a task representation strategy is proposed to represent each task by a vector that embeds the evolution information. Then, a task grouping strategy is proposed to group the similar (i.e., shift invariant) tasks into the same group while the dissimilar tasks into different groups. In the second evolution stage, a novel successful evolution experience transfer method is proposed to adaptively utilize the suitable parameters by transferring successful parameters among similar tasks within the same group. Comprehensive experiments are carried out on two representative MaTOP benchmarks with a total of 16 instances and a real-world application. The comparative results show that the proposed TRADE is superior to some state-of-the-art EMTO algorithms and single-task optimization algorithms.
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http://dx.doi.org/10.1109/TCYB.2023.3234969 | DOI Listing |
bioRxiv
August 2025
Department of Medicine, Division of Allergy and Clinical Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA, Broad Institute of MIT, and Harvard, Cambridge, MA 02139, USA, Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
A key goal of vaccinology is to train the immune system to combat current pathogens while simultaneously preparing it for future evolved variants. Understanding factors contributing to anticipatory breadth, wherein affinity maturation against an ancestral strain yields neutralization capacity against evolved variants, is therefore of great importance. Here, we investigated the mechanism of anticipatory breadth development in a public antibody family targeting the functionally restricted ACE2 binding site on SARS-CoV-2.
View Article and Find Full Text PDFPsychiatr Q
September 2025
Department of Psychology, Stockholm University, Stockholm, SE-106 91, Sweden.
The Patient Health Questionnaire-9 (PHQ-9) is a widely used tool for assessing depressive symptom severity and as a screening tool in the diagnosis of major depression. Designed as both a diagnostic instrument and a severity index, it is commonly used in primary care and research. However, findings regarding its reliability and validity for these dual purposes have been mixed.
View Article and Find Full Text PDFBiomed Phys Eng Express
September 2025
Zhejiang University, zhejiang, Hangzhou, Zhejiang, 310058, CHINA.
Medical image segmentation faces significant challenges in cross-domain scenarios due to variations in imaging protocols and device-specific artifacts. While existing methods leverage either spatial-domain features or global frequency transforms (e.g.
View Article and Find Full Text PDFNeural Netw
August 2025
Department of Statistical Sciences, University of Toronto, Ontario, Canada; Department of Computer Science, University of Toronto, Ontario, Canada; Department of Statistics and Data Science, MBZUAI, Abu Dhabi, UAE. Electronic address:
Mitigating catastrophic forgetting remains a fundamental challenge in incremental learning. This paper identifies a key limitation of the widely used softmax cross-entropy loss: the non-identifiability inherent in the standard softmax cross-entropy distillation loss. To address this issue, we propose two complementary strategies: (1) adopting an imbalance-invariant distillation loss to mitigate the adverse effect of imbalanced weights during distillation, and (2) regularizing the original prediction/distillation loss with shift-sensitive alternatives, which render the optimization problem identifiable and proactively prevent imbalance from arising.
View Article and Find Full Text PDFComput Biol Med
August 2025
Department of Radiation Oncology, UTSW, United States of America. Electronic address:
Accurate prediction of head and neck cancer recurrence across medical institutions remains challenging due to inherent domain shifts in imaging data. Current domain generalization methods primarily focus on learning domain-invariant features from medical images, often overlooking structured clinical information that inherently exhibits cross-institutional consistency. To leverage clinical data and enhance the model's generalization, we propose an end-to-end Language-Guided Multimodal Domain Generalization (LGMDG) method.
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