Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The accumulation and transmission of mechanical stresses in the cell cortex and membrane determines the mechanics of cell shape and coordinates essential physical behaviors, from cell polarization to cell migration. However, the extent that the membrane and cytoskeleton each contribute to the transmission of mechanical stresses to coordinate diverse behaviors is unclear. Here, we reconstitute a minimal model of the actomyosin cortex within liposomes that adheres, spreads and ultimately ruptures on a surface. During spreading, accumulated adhesion-induced (passive) stresses within the membrane drive changes in the spatial assembly of actin. By contrast, during rupture, accumulated myosin-induced (active) stresses within the cortex determine the rate of pore opening. Thus, in the same system, devoid of biochemical regulation, the membrane and cortex can each play a passive or active role in the generation and transmission of mechanical stress, and their relative roles drive diverse biomimetic physical behaviors.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043271 | PMC |
| http://dx.doi.org/10.1038/s42003-023-04684-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
End-to-end inverse design for programmable acoustic tweezers with simultaneous force and torque control by metasurfaces.
Sci Adv
September 2025
Department of Mechanics, School of Mechanical Engineering, Tianjin University, Tianjin 300350, China.
Acoustic tweezers leverage acoustic radiation forces for noncontact manipulation. One of the core bottlenecks in multidimensional manipulation is the lack of a systematic design methodology, which prevents the generation of an acoustic field that simultaneously meets the collaborative control requirements of multi-degree-of-freedom forces and torques, making it difficult to achieve precise control under conditions of stable suspension, high-frequency rotation, and complex spatial constraints. To address this challenge, we develop an end-to-end inverse design methodology for acoustic tweezers based on coding metasurfaces, establishing a dual-objective, dual-scale optimization paradigm.
View Article and Find Full Text PDFAn Overview of Destroying SARS-CoV-2 and Proof of the Relationship Between Climate Changes and Airborne Dust on SARS-CoV-2 Prevalence.
Vector Borne Zoonotic Dis
September 2025
Department of Mechanical Engineering, Yeungnam University, Gyeongsan, Korea.
In view of Corona pandemic, scientists have taken significant efforts to study and recognize the peculiarities of the SARS-CoV-2 outbreak in order to prevent it from spreading. It was discovered that the virus is spreading in many places and nations that have made significant progress in addressing environmental pollution or are not subject to dusty storms. Infections are growing again in the same country, with varied densities of sick persons depending on the weather and windy season.
View Article and Find Full Text PDFRisk mitigation of shared room ventilation and filtration on SARS-CoV-2 transmission: a multicenter test-negative study.
Infect Control Hosp Epidemiol
September 2025
Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Background: Admission to shared hospital rooms are a risk factor of healthcare-associated (HA) SARS-CoV-2. Quantifying the impact of engineering controls such as ventilation and filtration is essential to informing resource utilization and infection prevention guidelines.
Methods: Multicenter test-negative study of patients exposed to SARS-CoV-2 in shared rooms across five hospitals between January and October, 2022.
Developing a method to estimate aerosol generation during poultry slaughtering and defeathering in Bangladesh: An experimental study.
Build Environ
March 2025
National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Morgantown, West Virginia, USA.
Influenza viruses can be aerosolized when slaughtering infected chickens, which increases the risk of zoonotic transmission. We conducted pilot experiments to measure the concentrations of airborne particles <2.5 μm during slaughtering and defeathering of chickens to help identify methods that can minimize workers' exposure to potentially hazardous aerosol particles.
View Article and Find Full Text PDFFluorinated Graphene-Coated N95 Respirators for Enhanced Protection Against Viral Accumulation and Transmission.
Adv Eng Mater
July 2025
Department of Mechanical Engineering University of Nevada, Las Vegas, NV, US.
Highly contagious respiratory infection diseases such as COVID-19 can be transmitted by inhaling virus laden liquid droplets and short-range aerosols, released by an infected person. Particularly, in hospitals, spraying of the respiratory droplets containing pathogens from the conjunctiva or mucus of a susceptible person plays a key role in transferring the infectious diseases. N95 filtering respirators are a critical personal protective equipment.
View Article and Find Full Text PDF