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We consider the stability analysis of a two-dimensional model for post-burn contraction. The model is based on morphoelasticity for permanent deformations and combined with a chemical-biological model that incorporates cellular densities, collagen density, and the concentration of chemoattractants. We formulate stability conditions depending on the decay rate of signaling molecules for both the continuous partial differential equations-based problem and the (semi-)discrete representation. We analyze the difference and convergence between the resulting spatial eigenvalues from the continuous and semi-discrete problems.
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http://dx.doi.org/10.1007/s00285-023-01893-w | DOI Listing |
Front Pharmacol
August 2025
Senior Department of Burns & Plastic Surgery, Institute of Burn in the Fourth Medical Centre, Chinese PLA General Hospital, Beijing, China.
Background/objectives: Burns can cause severe physiological disturbances. Oral rehydration therapy (ORT) is an alternative to intravenous fluids. However, the World Health Organization-recommended oral rehydration solution (WHO-ORS) lacks specific components to address the critical physiological changes in patients with burns.
View Article and Find Full Text PDFMil Med Res
September 2025
Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, L8S 4K1, Canada.
Background: Although sepsis is known to be the leading cause of morbidity and mortality in adult burn patients, its epidemiology and impact are poorly understood. This study aims to address these gaps by further characterizing predictors of sepsis and comparing outcomes between septic and non-septic burn patients in different age groups.
Methods: We included patients (≥ 18 years) with thermal burn injuries ≥ 5% total body surface area (TBSA) admitted to two burn centers between 1 January 2006 and 30 June 2021, and 1 January 2023 and 6 April 2025.
J Burn Care Res
August 2025
School of Rehabilitation Medicine, Capital Medical University, Beijing 100068, China.
Contrast therapy (CT), alternating cooling and heating therapy, has been investigated for its potential benefits in treating soft tissue injuries in sports. This study examines the efficacy of CT in enhancing skin scald repair. We established a standardized rat scald burn model, and randomized the subjects to three groups: CT, cold therapy (COT), and untreated model control (MC).
View Article and Find Full Text PDFEur Burn J
July 2025
Firefighter's Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, DC 20010, USA.
Fluid resuscitation after thermal injury is paramount to avoid burn shock and restore organ perfusion. Both over- and under-resuscitation can lead to unintended consequences affecting patient outcomes. While many studies have examined systemic effects, limited data exist on how fluid resuscitation impacts burn wound progression in the acute period.
View Article and Find Full Text PDFJ Burn Care Res
August 2025
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, MA, USA.
Stigma is prejudice and discrimination resulting from negative stereotypes. Burn survivors have greater risk for stigmatization, potentially influencing quality of life. This study aims to characterize stigma and its predictors in the burn population.
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