Publications by authors named "Cameron S D'Orio"
Fluid resuscitation after thermal injury is paramount to avoid burn shock and restore organ perfusion. Both over- and under-resuscitation can lead to unintended consequences affecting patient outcomes. While many studies have examined systemic effects, limited data exist on how fluid resuscitation impacts burn wound progression in the acute period.
View Article and Find Full Text PDFLessons Learned Evaluating Ablative Fractional CO2 Laser for Burn-Related Donor Site Scars.
J Burn Care Res
August 2025
Hypertrophic scar (HTS) remains a comorbidity of burn injury, often requiring split-thickness skin grafting (STSG) and resulting in symptomatic HTS at grafted sites and STSG donor sites (DS). Literature supports the use of ablative fractional CO2 laser (FLSR) to treat HTS, however many trials lack control sites and tissue-level examinations. Given the widespread adoption of FLSR for HTS, delegation of non-treated scar sites for the sake of randomized controlled trials (RCT) is troubling for many clinicians.
View Article and Find Full Text PDFArticle Synopsis
- ECMO usage is increasing, but determining which patients will benefit the most is challenging, making risk stratification crucial.
- This study evaluated the impact of two biomarkers, SDC-1 and soluble thrombomodulin (sTM), on mortality rates in patients on venoarterial ECMO.
- Results showed that higher levels of sTM significantly correlate with increased mortality risk, while SDC-1 levels are marginally predictive; these findings suggest that incorporating these biomarkers could enhance existing scoring systems for better patient assessment.
Article Synopsis
- The study investigates the effectiveness of combining autologous skin cell suspension (ASCS) with meshed split-thickness skin grafts (mSTSG) for treating large burns, aiming to improve healing times and reduce aesthetic issues.
- Experiments conducted on pigs showed that wounds treated with ASCS had significantly faster re-epithelialization rates compared to those without ASCS, particularly noted on days 3, 5, and 7 post-grafting.
- However, despite the improved healing rates, the presence of ASCS did not affect the patterning of the scars, indicating that while ASCS enhances healing, it may not address visual scarring issues.