Mussel-Inspired Multifunctional Hydrogels with Adhesive, Self-Healing, Antioxidative, and Antibacterial Activity for Wound Healing.

ACS Appl Mater Interfaces

Nonwoven Technology Laboratory, Key Laboratory of Eco-Textiles, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, People's Republic of China.

Published: April 2023


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Article Abstract

Antibacterial hydrogel wound dressings with adhesive and antioxidant activity are desirable for treating skin injuries in clinical care. Hereby, a series of multifunctional hydrogel wound dressings with high adhesive, self-healing, antioxidant, and antibacterial activity were designed and fabricated using dopamine (DA) and quercetin (QT). The multifunctional hydrogels were constructed by the interpenetrated quaternized chitosan chain segments and polyacrylamide network. The catechol groups on DA, QT, and the quaternary ammonium groups in the hydrogel system endow hydrogels with high strength, excellent adhesion, and self-healing ability. The results confirmed the admirable hemocompatibility and remarkable antibacterial activity of the multifunction hydrogels against and . Consequently, multifunction hydrogels with satisfactory adhesive and antibacterial activity are appropriate alternative materials in the fields of tissue adhesive and wound dressing applications.

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http://dx.doi.org/10.1021/acsami.3c01065DOI Listing

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