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Antibacterial hydrogel wound dressings with adhesive and antioxidant activity are desirable for treating skin injuries in clinical care. Hereby, a series of multifunctional hydrogel wound dressings with high adhesive, self-healing, antioxidant, and antibacterial activity were designed and fabricated using dopamine (DA) and quercetin (QT). The multifunctional hydrogels were constructed by the interpenetrated quaternized chitosan chain segments and polyacrylamide network. The catechol groups on DA, QT, and the quaternary ammonium groups in the hydrogel system endow hydrogels with high strength, excellent adhesion, and self-healing ability. The results confirmed the admirable hemocompatibility and remarkable antibacterial activity of the multifunction hydrogels against and . Consequently, multifunction hydrogels with satisfactory adhesive and antibacterial activity are appropriate alternative materials in the fields of tissue adhesive and wound dressing applications.
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http://dx.doi.org/10.1021/acsami.3c01065 | DOI Listing |
Lasers Med Sci
September 2025
Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Microbial contamination of absorbable collagen membranes used in guided bone regeneration (GBR) may compromise healing outcomes. This study aimed to investigate whether the minimum inhibitory concentration (MIC) of hydrogen peroxide (HO) can improve the antibacterial effect of indocyanine green (ICG)-mediated antimicrobial photodynamic therapy (PDT) on absorbable collagen membranes while reducing the need for high HO concentrations. A laboratory-based model was developed using Streptococcus sanguinis and Staphylococcus aureus.
View Article and Find Full Text PDFFEMS Microbiol Lett
September 2025
Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Arthrospira platensis (Spirulina) is one the highly valuable cyanobacteria in food and pharmaceutical industry. The intracellular and extracellular polysaccharide (PS) extracts of A. platensis have been exhibited different biological functions.
View Article and Find Full Text PDFChem Commun (Camb)
September 2025
School of Pharmacy, Nantong University, Nantong, Jiangsu Province, 226001, China.
In recent years, photosensitizer-based phototherapy has gained increasing attention in antibacterial applications due to its low cost, noninvasive nature, and low drug resistance. Among various materials, porphyrin-based metal-organic frameworks (MOFs) have demonstrated great potential, due to their good biocompatibility, facile designability, and excellent light absorption capabilities that enable highly efficient antibacterial efficacy. However, further optimization of their antibacterial performance remains a key challenge.
View Article and Find Full Text PDFAdv Mater
September 2025
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Bone defect therapy frequently encounters bacterial infections and chronic inflammation, which impair bone regeneration and threaten implant stability. Iron oxide nanoparticles have attracted attention due to cost-effectiveness, biocompatibility, and metabolic safety. However, iron oxide nanoparticles still struggle to balance low-temperature efficient antibacterial activity, effective immunomodulation, and bone regeneration.
View Article and Find Full Text PDFJ Burn Care Res
September 2025
Shanghai Starriver Bilingual School, Shanghai, China.
Background: Despite the advancements of pharmacological treatments and gauze dressings in the field of skin wound healing, these methods present numerous limitations. Therefore, developing a multifunctional material capable of efficiently promoting skin wound healing is particularly crucial.
Methods: Citric acid (CA)-modified chitosan (CS) loaded with Shikonin (SK) (CA-CS-SK) hydrogel was prepared via the freeze-thaw method.