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http://dx.doi.org/10.3389/fpsyg.2023.1127477 | DOI Listing |
Front Immunol
September 2025
Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Introduction: Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is a neuropsychiatric disorder with additional psychiatric features caused by NMDA-R immunoglobulin G (IgG) antibodies in cerebrospinal fluid (CSF). This report presents the follow-up of a patient in whom we assumed mild NMDA-R encephalitis in the first psychotic episode.
Case Study: A patient with a prior episode of an acute polymorphic psychotic syndrome relapsed five and a half years later following a severe COVID-19 infection.
Front Psychiatry
August 2025
Statistics Section of the Department of Genetics, Microbiology and Statistics, Universitat de Barcelona (UB), Barcelona, Spain.
Most methodological Polygenic Risk Score (PRS)-related papers explain the laborious process of computing the PRS in great depth. Afterwards, as a last step, it is generally described that to test a possible association between a PRS and a trait of interest, an analysis through regression models (linear or logistic, depending on data type) should be carried out adjusting for covariates (e.g.
View Article and Find Full Text PDFNervenarzt
September 2025
Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, Augsburg, Germany.
The classification of psychotic disorders has undergone a variety of changes. Since Karl Ludwig Kahlbaum's (Kahlbaum 1874) first descriptions of catatonic states and Emil Kraepelin's (Kraepelin 1883) nosological classification of psychotic syndromes in the second half of the nineteenth century, the diagnostic criteria for these disorders have been repeatedly modified, significantly impacting clinical practice. Eugen Bleuler (Bleuler 1911) coined the term "schizophrenia", emphasizing the disturbances in thinking, feeling and acting that he had observed.
View Article and Find Full Text PDFFront Psychiatry
August 2025
Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, L'Aquila, Italy.
The glymphatic system is integral to the elimination of metabolic waste from the central nervous system and has been extensively studied in relation to neurodegenerative and cerebrovascular diseases. Emerging evidence suggests that glymphatic dysfunction may also play a role in psychiatric disorders, including psychosis and schizophrenia. This pilot study investigated glymphatic clearance in young adults hospitalized for an acute psychotic episode using the diffusion tensor imaging (DTI)-derived ALPS (Along Perivascular Spaces) index.
View Article and Find Full Text PDFAm J Psychiatry
September 2025
Department of Psychiatry, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI.