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Among the waste materials of wine production, grape seeds constitute an important fraction of the pomace, from which the precious edible oil is extracted. The residual mass from oil extraction, the defatted grape seeds (DGS), can be destined for composting or valorized according to the circular economy rules to produce pyrolytic biochar by gasification or pellets for integral energy recovery. Only a small quantity is used for subsequent extraction of polyphenols and tannins. In this study, we performed a chemical characterization of the DGS, by applying spectroscopic techniques (ICP-OES) to determine the metal content, separation techniques (HS-SPME-GC-MS) to evaluate the volatile fraction, and thermal methods of analysis (TGA-MS-EGA) to identify different matrix constituents. Our main goal is to obtain information about the composition of DGS and identify some bioactive compounds constituting the matrix in view of possible future applications. The results suggest that DGS can be further exploited as a dietary supplement, or as an enriching ingredient in foods, for example, in baked goods. Defatted grape seed flour can be used for both human and animal consumption, as it is a source of functional macro- and micronutrients that help in maintaining optimal health and well-being conditions.
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http://dx.doi.org/10.3390/life13020326 | DOI Listing |
ACS Nano
September 2025
Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China.
An interactive bidirectional relationship between periodontitis and diabetes poses great challenges for the treatment of diabetic periodontitis in clinical practice. The hyperglycemic inflammatory periodontal microenvironment is characterized by oxidative damage, chronic invasive infection, excessive inflammation, unbalanced immunomodulation, progressive neuropathy, diabetic vasculopathy, and uncoupled bone resorption and formation responses. The neuromodulation strategy holds great potential to mediate and coordinate temporally the complex microenvironment for diabetic periodontal regeneration.
View Article and Find Full Text PDFPlants (Basel)
August 2025
Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA), Consejo Superior de Investigaciones Científicas (CSIC), Cordel de Merinas, 40, 37008 Salamanca, Spain.
Seeds of different cultivars ( subsp. ) have an interesting diversity of shapes, ranging from the small seeds of high solidity and low aspect ratio in some species of and subsp. to other morphological types with elongated stalks, characteristic of the more recent cultivars, suggesting a transition with alterations in seed shape associated with groups of cultivars.
View Article and Find Full Text PDFFoods
August 2025
College of Enology, Northwest A&F University, Yangling 712100, China.
With the development of people's diets and working patterns, obesity is an increasingly serious health threat faced globally. Grape pomace is an important by-product generated during the wine production process which is rich in polyphenols. Polyphenols show promising potential in anti-inflammatory, antioxidant, and metabolic regulatory applications.
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August 2025
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, PR China; Jiangsu Key Laboratory of Medicinal Substance and Utilization of Fresh Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:
This study developed functional soybean protein isolate (SPI)-based films incorporated with plant-derived oleosomes (mustard, grape, and chili seeds) and systematically evaluated their physicochemical properties, antioxidant and antimicrobial activities, and food preservation efficacy. Films were fabricated by integrating oleosomes into SPI matrices, followed by solvent casting. Physicochemical characterization revealed that films with grape seed oleosomes provided the most significant improvements compared to control SPI films: reduced transparency (56 %), water vapor permeability (11 %), and lipid peroxidation (43 % lower peroxide value); increased hydrophobicity (contact angle +20 %) and flexibility (elongation at break +16 %).
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