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Preschool-aged children's performance on inhibitory control tasks is typically represented by the overall accuracy of their item responses (e.g., mean proportion correct). However, in settings where children vary widely in age or ability level, inhibitory control tasks are susceptible to ceiling effects, which undermine measurement precision. We have previously demonstrated a general approach for scoring inhibitory control tasks that combines item-level accuracy and reaction-time information to minimize ceiling effects. Here, we extend that approach by incorporating additional item-level reaction time data from an adjunct (simple reaction time) task. We contrast three approaches for scoring inhibitory control tasks, two of which rely exclusively on item accuracy information and a third which also considers item reaction time information. We demonstrate the impacts of these different approaches to scoring with two inhibitory control tasks that were included in a recent evaluation of the Red Light, Purple Light intervention in preprimary classrooms in Nairobi County, Kenya. We limited our study to children who met inclusion criteria at pre-test ( = 418; 51% male; mean age = 4.8 years) or post-test ( = 386; 51% male; mean age = 4.8 years). Children's performance on individual inhibitory control tasks was strongly correlated regardless of the scoring approach (s = 0.73-0.97 across two tasks). However, the combined accuracy and reaction time scores eliminated ceiling effects that were common when only accuracy information was used. The combined accuracy and reaction time models also distinguished item-level RT into inhibitory control and processing speed components, which are distinct constructs. Results are discussed with respect to the challenges and nuances of the estimation and interpretation of inhibitory control task scores with children of varied ages and ability levels.
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http://dx.doi.org/10.3389/fpsyg.2023.861441 | DOI Listing |
Front Microbiol
August 2025
Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous economic losses in the swine industry since emerging in the late 1980s. Although vaccination has been widely used to control PRRS epidemics in Chinese pig farms, they provided limited protection against PRRSV transmission; moreover, no effective therapeutic drugs are available. Therefore, there is an urgent need to develop novel antiviral strategies to control PRRSV epidemics.
View Article and Find Full Text PDFPsychoradiology
August 2025
Department of Radiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Background: Despite advances in understanding the effective connectivity (EC) of brain networks in leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis, the specific cause and underlying mechanisms of LGI1 encephalitis remain unclear.
Materials And Methods: The study included 27 patients with anti-LGI1 encephalitis and 28 age- and sex-matched normal controls. Amplitude of low-frequency fluctuation (ALFF) analysis identified altered brain regions.
Cureus
August 2025
Internal Medicine, King Fahad Specialist Hospital, Dammam, SAU.
Candidemia, a common hospital-acquired bloodstream infection, is associated with significant mortality, particularly in cases involving (). The Middle East, including Saudi Arabia, has seen an increasing number of invasive infections. This review examines the epidemiology, risk factors, antifungal susceptibility, clinical manifestations, and mortality associated with , based on published literature from Saudi Arabia.
View Article and Find Full Text PDFOncol Res
September 2025
Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.
Objectives: The Sorbin and SH3 domain containing 1 (SORBS1), a protein linked to insulin signaling CBL interaction, was investigated for its role in pancreatic cancer apoptosis. This study explored polyphyllin H (PPH)'s ability to restore SORBS1-knockdown-mediated repair functions.
Methods: PANC-1 cells were divided into Blank, overexpression (OE), and knockdown groups.
Front Immunol
September 2025
Department of Infectious Diseases, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, China.
Objective: Enterovirus 71 (EV-A71) is a major pathogen of severe hand, foot and mouth disease (HFMD) in children, but the mechanism by which it develops into severe HFMD remains unclear, especially the role of macrophage-mediated immune dysregulation.
Methods: Bioinformatics tools were utilized to analyze the transcriptome sequencing results of peripheral blood monocytes (PBMCs) infected with different titers of EV-A71 at various time points. Single-cell sequencing technology was used to sequence obtained PBMCs from a severe HFMD patient due to EV-A71 and a healthy control.