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A 24-year-old female patient was referred to our hospital with the diagnosis of Ewing's sarcoma localized in the left distal tibia. Neoadjuvant chemotherapy was completed for the patient who had localized disease. En-bloc resection of the tumor segment in the diaphyseal tibia, intraoperative extracorporeal radiotherapy, and then re-implantation of the segment after clearing the tumor were performed. Transfer of the ipsilateral pedicled fibula to the medulla of the irradiated segment was performed. As far as we know, the simultaneous application of extracorporeal radiotherapy and the re-implantation method after resection of the tibial tumoral segment and the transfer of the ipsilateral fibula with its pedicle has not been previously reported in the literature. In this case, this new technique was accompanied by a satisfactory result.
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http://dx.doi.org/10.7759/cureus.33526 | DOI Listing |
Brain Res Bull
September 2025
Academy of Medical Engineering and Translation Medicine, Tianjin University, Tianjin 300072, China.
Brain tumors are one of the most dangerous cancers with serious effects on human health. The primary treatment approach involves a combination of surgery, supplemented by postoperative radiotherapy. The growth pattern of malignant tumor is typically infiltrative, posing a challenge in visually distinguishing the tumor from the surrounding normal brain tissue during surgery.
View Article and Find Full Text PDFJ Clin Orthop Trauma
November 2025
JIPMER, Pondicherry, 605006, India.
Background: Extracorporeally irradiated autografts at an osteoarticular location following resection of malignant bone tumors have unique considerations. While oncological outcomes remain similar to other modes of treatment, joint function is directly affected due to the articular location of the autograft. There is limited literature focusing specifically on long-term functional outcomes in such reconstructions.
View Article and Find Full Text PDFBone Marrow Transplant
July 2025
Hematology and SCT Unit, S. Maria della Misericordia Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
BJU Int
August 2025
Department of Urology, LMU Klinikum, Munich, Germany.
Objective: To compare the perioperative complications of the most common focal therapy (FT) modalities for prostate cancer.
Patients And Methods: We assessed the GeRmAn Nationwide inpatient Data (GRAND) from 2005 to 2023, provided by the Research Data Center of the Federal Bureau of Statistics. We compared perioperative outcomes of high-intensity focused ultrasound (HIFU), hyperthermia, irreversible electroporation of the prostate, cryotherapy, vascular photodynamic therapy of the prostate (VTP), and transurethral ultrasound ablation, as well as HIFU vs non-HIFU treatments in general.
Lasers Med Sci
April 2025
College of Physical Therapy, Misr University for Science and Technology, Giza, Giza, Egypt.
This systematic review aimed to compare the effectiveness of Extracorporeal Shock Wave Therapy (ESWT) versus Laser therapy (Low-Level Laser Therapy (LLLT) and High-Intensity Laser Therapy (HILT) in treating musculoskeletal disorders (MSKDs). Systematic searches of randomized clinical trials (RCTs) were performed in six databases from inception till February 2025. Two researchers independently screened titles, abstracts, and full-text articles.
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