98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.addr.2023.114729 | DOI Listing |
Vestn Oftalmol
September 2025
OOO Diagnosticheskij tsentr Zreniye, Saint Petersburg, Russia.
Objective: This study evaluated the effect of sequential therapy with different dosages of Mexidol on the stabilization of glaucomatous optic neuropathy (GON) in patients with primary open-angle glaucoma (POAG).
Material And Methods: The study included 80 patients (160 eyes) with stage II and III POAG, randomized into three groups comparable by age, gender, and distribution of glaucoma stage. All patients received sequential therapy with Mexidol (14 days parenterally followed by 90 days orally).
Cancer Discov
September 2025
Evolutionary Dynamics Group, Centre for Cancer Evolution, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.
Unlabelled: Oncogenes amplified on extrachromosomal DNA (ecDNA) contribute to treatment resistance and poor survival across cancers. Currently, the spatiotemporal evolution of ecDNA remains poorly understood. In this study, we integrate computational modeling with samples from 94 treatment-naive human glioblastomas (GBM) to investigate the spatiotemporal evolution of ecDNA.
View Article and Find Full Text PDFAdv Mater
September 2025
Key Lab of Artificial Micro- and Nano-Structures of Ministry of Education of China, School of Physics and Technology, Wuhan University, Wuhan, 430072, China.
Sequential deposition technique is widely used to fabricate perovskite films with large grain size in perovskite solar cells (PSCs). Residual lead halide (PbI) in the perovskite film tends to be decomposed into metallic lead (Pb) under long-term heating or light soaking. Here, a chiral levetiracetam (LEV) dopant containing α-amide and pyrrolidone groups is introduced into the PbI precursor solution.
View Article and Find Full Text PDFAdv Mater
September 2025
Center for Renewable Energy and Storage Technologies (CREST), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
The orientation of MXene flakes has received increasing research attention as it plays a critical role in determining the performance of MXene-based assemblies. Engineering MXene flakes into horizontal or vertical orientations can offer distinct advantages such as higher electrical conductivity, higher mechanical strength, and more efficient ion/molecule transport across the flakes. However, the benefits of horizontal and vertical orientations are mutually exclusive, and both of them possess structural symmetry that restricts their ability for stimuli-responsive deformation.
View Article and Find Full Text PDFMicrobiol Spectr
September 2025
Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
is a commensal bacterium that colonizes the gut of humans and animals and is a major opportunistic pathogen, known for causing multidrug-resistant healthcare-associated infections (HAIs). Its ability to thrive in diverse environments and disseminate antimicrobial resistance genes (ARGs) across ecological niches highlights the importance of understanding its ecological, evolutionary, and epidemiological dynamics. The CRISPR2 locus has been used as a valuable marker for assessing clonality and phylogenetic relationships in .
View Article and Find Full Text PDF