Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Tobacco smoking is deleterious to the lungs because it exposes them to many toxic substances. These include transition metal ions, such as cadmium. However, there is a lack of information about the influence of endogenous metal-binding peptides, such as His-Leu (HL), on the lung distribution of transition metals in smokers. To address this, we administered HL subcutaneously to rats exposed to tobacco smoke for six weeks, then we measured the concentrations of transition metal ions in the lungs. We found that exposure to tobacco smoke elevates the concentrations of Cd(II) and Cu(II). Administration of the HL peptide, whose elevation is a consequence of angiotensin receptor blocker anti-hypertension therapy, increases the concentration of Fe in the lungs of rats exposed to smoke. These findings suggest that smoking is a risk factor for patients receiving angiotensin receptor blockers to treat hypertension.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862342 | PMC |
| http://dx.doi.org/10.3390/molecules28020628 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Precursor Engineering of Atomic Layer Deposition for Top-Gate Insulators on Monolayer MoS Transistors.
ACS Nano
September 2025
Department of Chemical Engineering, Stanford University, Stanford, California 94305, United States.
Integration of ultrathin, high-quality gate insulators is critical to the success of two-dimensional (2D) semiconductor transistors in next-generation nanoelectronics. Here, we investigate the impact of atomic layer deposition (ALD) precursor choice on the nucleation and growth of insulators on monolayer MoS. Surveying a series of aluminum (AlO) precursors, we observe that increasing the length of the ligands reduces the nucleation delay of alumina on monolayer MoS, a phenomenon that we attribute to improved van der Waals dispersion interactions with the 2D material.
View Article and Find Full Text PDFElectroreductive Denitrogenation of Tetrazolo[1,5-]quinoxalin-4(5)-ones to 3-Aminoquinoxalin-2(1)-ones.
J Org Chem
September 2025
Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Jadavpur, Kolkata 700 032, India.
The denitrogenation of tetrazoles is typically performed using transition-metal catalysts at high temperatures due to the inherent stability of the tetrazole group. In this work, we present, for the first time, an electrochemical method for denitrogenating tetrazoles at room temperature. This method employs a sacrificial zinc anode and a platinum cathode in a solvent mixture of acetonitrile and water under a constant current in an undivided cell.
View Article and Find Full Text PDFPhotocatalyzed Synthesis of Coumarin-3-Derivatives from Aryl Alkynoates and Hydrazines.
J Org Chem
September 2025
Department of Chemistry, Indian Institute of Technology Delhi, New Delhi 110016, India.
We demonstrate a direct synthesis of coumarin-3 derivatives from aryl alkynoates and hydrazines in visible light, photocatalyzed by rose bengal. The method is facile, transition-metal-free, versatile, and furnishes various 3-functionalized coumarins such as ester, acyl, aryl, carbamoyl, and sulfonyl in moderate to good yields, with the respective hydrazine reagent serving as the radical precursor. Two anti-TB molecules, and , were synthesized using this method.
View Article and Find Full Text PDFConducting Domain Walls in van der Waals Ferroelectric NbOI.
Nano Lett
September 2025
Department of Physics and Astronomy, University of Nebraska─Lincoln, Lincoln, Nebraska 68588, United States.
In this study, using a set of scanning probe microscopy techniques, we investigate the electronic properties of the domain walls in the layered ferroelectric semiconductor of the transition metal oxide dihalide family, NbOI. Although the uniaxial ferroelectricity of NbOI allows only 180° domain walls, the pristine 2D flakes, where polarization is aligned in-plane, typically exhibit a variety of as-grown domain patterns outlined by the electrically neutral and charged domain walls. The electrically biased probing tip can modify the as-grown domain structures.
View Article and Find Full Text PDFBond Dissociation Energies of RuC, RhC, OsC, IrC, and PtC Measured by Resonant Three-Photon Ionization Spectroscopy.
J Phys Chem A
September 2025
Department of Chemistry, University of Utah, Salt Lake City, Utah 84112-0850, United States.
Resonant three-photon ionization spectroscopy has been used to study the late 4d and 5d transition metal carbides RuC, RhC, OsC, IrC, and PtC. These species, like most diatomic transition metals with open nd subshells, exhibit an exceptionally high density of states near the ground separated atom limit. Spin-orbit and nonadiabatic interactions provide a means for the molecules to rapidly dissociate as soon as the bond dissociation energy (BDE) is exceeded.
View Article and Find Full Text PDF