Electroreductive Denitrogenation of Tetrazolo[1,5-]quinoxalin-4(5)-ones to 3-Aminoquinoxalin-2(1)-ones.

The denitrogenation of tetrazoles is typically performed using transition-metal catalysts at high temperatures due to the inherent stability of the tetrazole group. In this work, we present, for the first time, an electrochemical method for denitrogenating tetrazoles at room temperature. This method employs a sacrificial zinc anode and a platinum cathode in a solvent mixture of acetonitrile and water under a constant current in an undivided cell.

Optimization of multifunctional NaYbF:Er upconversion nanoparticle-based dual drug delivery system for enhanced chemo-photodynamic therapy in prostate cancer.

Upconversion efficiency in heterostructure hosts is critical for multicolor emission in biomedical applications, where cellular uptake is dependent on particle size. In chemo-photodynamic therapy (chemo-PDT), reducing cellular glutathione (GSH) levels through reactive nitrogen species (RNS) generation, combined with reactive oxygen species (ROS), offers a dual strategy to halt cancer cell proliferation. Herein, We optimized NaYbF:Er upconversion nanoparticles (UCNPs) with size control (final nanocapsule size: 60.

A TEMPO-N Complex Enables the Electrochemical C-H Azidation of N-Heterocycles through the Cleavage of Alkoxyamines.

A TEMPO-N charge-transfer complex enables the electrochemical C-H azidation of various N-heterocycles. The TEMPO ion, generated from TEMPO, assists in producing N by forming a TEMPO-N complex with N . The formation of this complex is supported by UV-vis absorption spectra, cyclic voltammetry studies, and ESI-HRMS studies.

Convergent Paired Electrolysis for [3+2] Cycloaddition of Azidotrimethylsilane with N-Heterocycles.

A widely used method to obtain tetrazoles is through the azide and nitrile [3+2] cycloaddition. However, this process often involves using non-recyclable transition metals or Lewis acid catalysts and stoichiometric amounts of oxidants and additives, which reduces atom efficiency. We have discovered a convergent paired electrochemical reaction to perform this cycloaddition reaction, without the need for metal catalysts or oxidants.

Community-based study to describe the epidemiology of dengue infection in a large cantonment during one transmission season.

Background: Dengue is one of the most important vector-borne disease in India. It has been linked to monsoons when mosquitoes breed profusely in containers. No study exists in Armed Forces wherein a community-based sero-survey has described the epidemiology of dengue.

A Rare Case of Grisel's Syndrome in A 6-Year-Old Child.

Introduction: C1-2 rotatory subluxation is more commonly seen in children compared to in adults. It often has a history of respiratory tract infection, cervical trauma, and recent history of surgery of the head or neck.

Case Report: A 6-year-old boy presented to us with complaints of insidious onset of progressive deformity of the neck since the past 3 months.

Serodiagnosis of multiple cancers using an extracellular protein kinase A autoantibody-based lateral flow platform.

Extracellular protein kinase A autoantibody (ECPKA-AutoAb) has been suggested as a universal cancer biomarker due to its higher amounts in serum of several types of cancer patients than that of normal individuals. Herein, we first developed a lateral flow immunoassay (LFIA) tool, using a sandwich format, toward ECPKA-AutoAb in human serum. For this format, 3G2 as a capture antibody was identified using hybridoma technique and a series of screenings where it showed superior capacity to recognize Enzo PKA catalytic subunit alpha (Cα), compared to other PKA antibodies and antigens.

Supporting Electrolyte-Free Electrochemical Oxidative C-H Sulfonylation and Thiocyanation of Fused Pyrimidin-4-Ones in an All-Green Electrolytic System.

An electrooxidative C-H functionalization is a widely accepted route to obtain sulfur-containing arenes and heteroarenes. However, this process often involves using non-recyclable supporting electrolytes, (co)solvents like hexafluoroisopropanol, additives like acid, or catalysts. The use of additional reagents can increase costs and waste, reducing atom efficiency.

Fluorescence "Turn OFF-ON" detection of Fe and propiconazole pesticide using blue emissive carbon dots from lemon peel.

In this study, water-soluble carbon dots (CDs) were employed as a novel fluorescence "turn OFF-ON" sensor to detect Fe ions in pharmaceutical sample and propiconazole (PC) in food samples. Blue fluorescent "LPCDs" are synthesized from the lemon peel that exhibited emission at 468 nm when excited at 378 nm. The average size of the as-prepared LPCDs is 2.

Synthesis of multicolor silver nanostructures for colorimetric sensing of metal ions (Cr, Hg and K) in industrial water and urine samples with different spectral characteristics.

In this work, we have synthesized four different color (yellow, orange, green, and blue (multicolor)) silver nanostructures (AgNSs) by chemical reduction method where silver nitrate, sodium borohydride and hydrogen peroxide were used as reagents. The as-synthesized multicolor AgNSs were successfully functionalized with bovine serum albumin (BSA) and applied as a colorimetric sensor for the assaying of metal cations (Cr, Hg, and K). The addition of metal ions (Cr, Hg, and K) into BSA functionalized AgNSs (BSA-AgNSs) causes the aggregation of BSA-AgNSs, and are accompanied by visual color changes with red or blue shift in the surface plasmon resonance (SPR) band of BSA-AgNSs.

Sensitive Detection of BVDV Using Gold Nanoparticle-Modified Few-Layer Black Phosphorus with Affinity Peptide-Based Electrochemical Sensor.

The lethality of the bovine viral diarrhea virus (BVDV) in cattle involves inapparent infection and various, typically subclinical, syndromes. Cattle of all ages are vulnerable to infection with the virus. It also causes considerable economic losses, primarily due to reduced reproductive performance.

Integrating Regioselective E→Z Isomerization of Trienones with Cascade Sequences under Photosensitizer-Free Direct Irradiation at 390 nm.

The regioselective E→Z isomerization of a target olefin unit embedded in a conjugated polyene is challenging. Examples are limited to retinal and its derivatives only. The problem is further amplified when such an isomerization is integrated into cascade sequences, among which the regioselectivity and subsequent directionality are the major bottlenecks.

Hydroxychloroquine/Chloroquine Prophylaxis among Health-care Workers: Was it Really Preventive? - Evidence from a Multicentric Cross-sectional Study.

Background: Despite the low level of clinical evidence in hydroxychloroquine (HCQ) favor, it was prescribed for pre- and post-exposure prophylaxis in India and worldwide. In absence of a large randomized control trial, the evidence needs to be generated through observation study, hence the study was conducted to find the evidence for prophylaxis of HCQ.

Materials And Methods: A multi-centric cross-sectional study involving government hospitals was chosen for serosurvey conducted from August 21, 2020, to November 20, 2020.

An iron-catalyzed domino reaction of donor-acceptor cyclopropanes: a diastereoselective approach towards diversely functionalized pyrrolo-quinazolines.

An expeditious synthetic route to access functionalized pyrrolo[2,1-]quinazoline scaffolds has been achieved domino ring opening cyclization (DROC) reactions of donor-acceptor (D-A) cyclopropanes and 2-amino(methyl)aniline derivatives. This novel iron catalyzed transformation is amenable to a wide range of substrates. Three new C-N bonds and two rings were sequentially constructed in this divergent one-pot process.

Seropositivity of severe acute respiratory syndrome coronavirus 2 infection among healthcare workers of the Armed Forces medical services, India: A multicentric study.

Background: Serosurveys provide the prevalence of infection and over time will reveal the trends. The present study was conducted to estimate the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers (HCWs) and to analyse various characteristics (risk factors) associated with SARS CoV-2 infection.

Methods: Eight government designated Corona virus disease -19 (COVID-19) hospitals were selected based on the hospital admission of patients with COVID-19 and the local epidemiological situation in the region.

COVISHIELD (AZD1222) VaccINe effectiveness among healthcare and frontline Workers of INdian Armed Forces: Interim results of VIN-WIN cohort study.

Background: On 16 Jan 2021, India launched its immunization program against COVID-19. Among the first recipients were 1.59 million Health Care Workers (HCWs) and Frontline Workers (FLWs) of the Indian Armed Forces, who were administered COVISHIELD (Astra Zeneca).

Facile synthesis of carbon dots from Tagetes erecta as a precursor for determination of chlorpyrifos via fluorescence turn-off and quinalphos via fluorescence turn-on mechanisms.

Convenient one-pot synthetic route for the fabrication of carbon dots (CDs) from Tagetes erecta flower (TEF), named as "TEF-CDs', through solvo(hydro)-thermal carbonization of the TEF was developed. The TEF-CDs revealed high selectivity towards chlorpyrifos and quinalphos, acting as a fluorescent probe. The CDs synthesized from T.

Trypsin mediated one-pot reaction for the synthesis of red fluorescent gold nanoclusters: Sensing of multiple analytes (carbidopa, dopamine, Cu, Co and Hg ions).

Herein, we fabricated fluorescent gold nanoclusters (Au NCs) by using trypsin as a ligand. The fabricated trypsin-Au NCs emit bright red color fluorescence upon the exposure of 365 nm UV light. The trypsin-Au NCs are stable and well dispersed in water, which exhibited strong red emission peak at 665 nm upon excitation wavelength of 520 nm.

Occurrence of a novel tannase ( ) in endophytic sp. AL1L from the leaf of Roxb.

The tannase production ability by endophytic actinobacteria and the genetic identity of responsible tannase gene were determined. The studied strains were isolated from surface-sterilized leaf discs of Roxb. Four strains were found to hydrolyze tannic acid on solid media containing 0.

Anti-Infective Metabolites of a Newly Isolated Bacillus thuringiensis KL1 Associated with Kalmegh (Andrographis paniculata Nees.), a Traditional Medicinal Herb.

This study was conducted to isolate endophytic bacteria possessing anti-infective property from Kalmegh (Andrographis paniculata Nees.), a well-known medicinal plant. A total of 23 strains were isolated from this plant among which the strain KL1, isolated from surface-sterilized leaf of this medicinal herb, showed broad-spectrum antagonism against an array of Gram-positive and -negative bacterial pathogens.

Functionalised Mn(VI)-nanoparticles: an advanced high-valent magnetic catalyst.

We discover Mn(VI)-nanoparticles (NPs) bearing functional groups, high oxidation state, strong electron affinity, unique redox and paramagnetic nature, which opens up a new avenue to catalysis, magnetism and material application. However, its synthesis is challenging and remains unexplored because of associated serious difficulties. A simple benign synthetic strategy is devised to fabricate the high-valent NPs using mild reducing agent bromide, which transformed Mn(VII) to valuable Mn(VI)-species.