Publications by authors named "Subham K Bandyopadhyay"
Article Synopsis
- Acute myeloid leukemia (AML) is a complex and aggressive cancer with poor outcomes and few effective targeted treatments; KDM6 proteins play a key role in its development by regulating genes linked to DNA damage repair.
- Research shows that KDM6A and KDM6B are essential for activating these repair mechanisms, and mutations in KDM6A can lead to chemotherapy resistance, though some relapsed AML cases show increased levels of KDM6A.
- The study suggests that combining inhibitors targeting KDM6A with PARP and BCL2 can enhance cancer cell death, making it a promising new treatment approach for AML, highlighting the importance of KDM6A in predicting treatment response.
