Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Diabetes mellitus represents one of the most frequent comorbidities among patients with COVID-19, constituting a risk factor for a more severe prognosis than that of non-diabetic patients. However, the pathophysiological mechanism underlying this unfavorable outcome is still not completely clear. The goal of our study was to evaluate the potential role of antidiabetic therapy in the evolution of COVID-19.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865860 | PMC |
| http://dx.doi.org/10.3390/microorganisms11010145 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Quantitative Analysis of Kurtosis Impact on Occupational Complex Noise-Induced Hearing Loss.
Am J Ind Med
September 2025
National Institute for Occupational Safety and Health, Division of Field Studies and Engineering, Cincinnati, Ohio, USA.
Background: Workers in industry settings are often exposed to complex noise, which poses a greater risk to hearing loss than continuous noise at equivalent energy levels. Previous studies have identified kurtosis as an essential metric for evaluating complex noise-induced hearing loss (NIHL). This study aimed to characterize the distribution of workers exposed to complex noise, examine the associations between kurtosis and changes in hearing thresholds at various frequencies, and explore kurtosis's role in estimating NIHL and its integration into occupational hearing loss prevention programs.
View Article and Find Full Text PDFImpact of Mechanical and Architectural Signals in the Tumor Microenvironment on Melanoma.
Adv Healthc Mater
September 2025
Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, 11794, USA.
Compared to sun-exposed melanomas, acral melanomas are genetically diverse and occur in areas with low sun exposure and high mechanical loads. During metastatic growth, melanomas invade from the epidermis to the dermis layers through dense tumor stroma and are exposed to fibrillar collagen architectures and mechanical stresses. However, the role of these signals during acral melanoma pathogenesis is not well understood.
View Article and Find Full Text PDFTargeting O-GlcNAcylated METTL3 impedes MDS/AML progression via diminishing SRSF1 mA modification.
Mol Ther
September 2025
Xi'an No. 1 Hospital, First Affiliated Hospital of Northwest University, School of Medicine, Xi'an, China; Key Laboratory of Resource Biology and Biotechnology of Western China, Ministry of Education; Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi'an,
N6-methyladenosine (mA) modification, primarily regulated by methyltransferase-like protein 3 (METTL3), plays a pivotal role in RNA metabolism and leukemogenesis. However, the post-translational mechanisms governing METTL3 stability and function remain incompletely understood. Given the widespread occurrence of O-GlcNAcylation on nuclear and cytosolic proteins, we hypothesized that METTL3 might undergo O-GlcNAcylation, thereby influencing its stability and oncogenic function in myeloid malignancies.
View Article and Find Full Text PDFFine tuning wheat development for the winter to spring transition.
Plant Commun
September 2025
School of Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK; Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Seeland, Germany. Electronic address:
The coordination of floral developmental stages with the environment is important for reproductive success and the optimization of crop yields. The timing of different developmental stages contributes to final yield potential with optimal adaptation enabling development to proceed without being impacted by seasonal weather events, including frosts or end of season drought. Here we characterise the role of FLOWERING LOCUS T 3 (FT3) in hexaploid bread wheat (Triticum aestivum) during the early stages of floral development.
View Article and Find Full Text PDFPrognostic role of the baseline neutrophil‒eosinophil ratio in cancer patients: a meta-analysis and systematic review.
World J Surg Oncol
September 2025
Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Background: Inflammation impacts the prognosis of numerous types of tumors. Inflammatory indicators such as the neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and neutrophil-to-eosinophil ratio (NER) have emerged as potential prognostic markers and are closely correlated with the outcomes of cancer patients. However, the connection between NER and cancer prognosis remains incompletely understood.
View Article and Find Full Text PDF