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(1) Background: Elders have higher rates of rehospitalization, especially those with functional decline. We aimed to investigate potential predictors of 30-day readmission risk by comprehensive geriatric assessment (CGA) in hospitalized patients aged 65 years or older and to examine the predictive ability of the LACE index and HOSPITAL score in older patients with a combination of malnutrition and physical dysfunction. (2) Methods: We included patients admitted to a geriatric ward in a tertiary hospital from July 2012 to August 2018. CGA components including cognitive, functional, nutritional, and social parameters were assessed at admission and recorded, as well as clinical information. The association factors with 30-day hospital readmission were analyzed by multivariate logistic regression analysis. The predictive ability of the LACE and HOSPITAL score was assessed using receiver operator characteristic curve analysis. (3) Results: During the study period, 1509 patients admitted to a ward were recorded. Of these patients, 233 (15.4%) were readmitted within 30 days. Those who were readmitted presented with higher comorbidity numbers and poorer performance of CGA, including gait ability, activities of daily living (ADL), and nutritional status. Multivariate regression analysis showed that male gender and moderately impaired gait ability were independently correlated with 30-day hospital readmissions, while other components such as functional impairment (as ADL) and nutritional status were not associated with 30-day rehospitalization. The receiver operating characteristics for the LACE index and HOSPITAL score showed that both predicting scores performed poorly at predicting 30-day hospital readmission (C-statistic = 0.59) and did not perform better in any of the subgroups. (4) Conclusions: Our study showed that only some components of CGA, mobile disability, and gender were independently associated with increased risk of readmission. However, the LACE index and HOSPITAL score had a poor discriminating ability for predicting 30-day hospitalization in all and subgroup patients. Further identifiers are required to better estimate the 30-day readmission rates in this patient population.
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http://dx.doi.org/10.3390/ijerph20010348 | DOI Listing |
Eur J Cardiothorac Surg
July 2025
Division of Thoracic Surgery, Department of Surgery, Kindai University Faculty of Medicine, Osaka-Sayama 589-8511, Japan.
Objectives: Adjuvant osimertinib is currently the standard of care after pulmonary resection in patients with non-small cell lung cancer (NSCLC) harbouring an activating epidermal growth factor receptor (EGFR) mutation. Several guidelines recommended up to 4 cycles of adjuvant platinum-doublet before adjuvant osimertinib treatment. However, whether adjuvant platinum-doublet prolongs the overall survival (OS) of patients with EGFR-mutated NSCLC as it did in the unselected LACE meta-analysis cohort is unclear.
View Article and Find Full Text PDFMod Pathol
July 2025
James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
GLI1 (glioma-associated oncogene homologue 1) altered neoplasms are an emerging group of tumors of presumed mesenchymal derivation, which occur mostly in the head and neck or soft tissues of the trunk and extremities. We have recently identified 4 ovarian neoplasms with GLI1 gene fusions; all were initially diagnosed as unusual sex cord-stromal tumors (n = 3) or endometrioid adenocarcinoma with sex cord-like morphology (n = 1). Patients' age ranged from 11 to 70 years and tumor size from 3 to 15 cm; all were confined to the ovary.
View Article and Find Full Text PDFHepatol Commun
August 2025
Leeds Liver Unit, St James's University Hospital, Leeds, UK.
Background: Alcohol associated liver disease (ALD) is a common condition that is a significant global cause of morbidity and mortality. Diabetes mellitus (DM) increases the risk of adverse outcomes in other types of steatotic liver disease. This retrospective study sought to explore the relationship between ALD and DM.
View Article and Find Full Text PDFRNA-protein interactions are fundamental to cellular processes such as gene regulation and RNA metabolism. Over the past decade, significant advancements in methodologies have transformed the ability to study these interactions with unprecedented resolution and specificity. This review systematically compares RNA- and protein-centric approaches, highlighting their strengths, limitations, and optimal applications.
View Article and Find Full Text PDFNephrology (Carlton)
July 2025
Department of Renal Medicine, Singapore General Hospital, Singapore.
Aim: Chronic kidney disease is associated with frequent readmissions for ambulatory-sensitive conditions such as fluid overload. There is a paucity of literature to identify individuals at high risk of fluid overload or all-cause readmissions.
Methods: We performed a single-centre retrospective cohort study involving 783 patients with an estimated glomerular filtration rate of 11-30 mL/min/1.