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Unlabelled: Temporal networks are an effective way to encode temporal information into graph data losslessly. Finding the bursting cohesive subgraph (BCS), which accumulates its cohesiveness at the fastest rate, is an important problem in temporal networks. The BCS has a large number of applications, such as representing emergency events in social media, traffic congestion in road networks and epidemic outbreak in communities. Nevertheless, existing methods demand the BCS lasting for a time interval, which neglects the timeliness of the BCS. In this paper, we design an early bursting cohesive subgraph (EBCS) model based on the k-core to enable identifying the burstiness as soon as possible. To find the EBCS, we first construct a time weight graph (TWG) to measure the bursting level by integrating the topological and temporal information. Then, we propose a global search algorithm, called GS-EBCS, which can find the exact EBCS by iteratively removing nodes from the TWG. Further, we propose a local search algorithm, named LS-EBCS, to find the EBCS by first expanding from a seed node until obtaining a candidate k-core and then refining the k-core to the result subgraph in an optimal time complexity. Subsequently, considering the situation that the massive temporal networks cannot be completely put into the memory, we first design an I/O method to build the TWG and then develop I/O efficient global search and local search algorithms, namely I/O-GS and I/O-LS respectively, to find the EBCS under the semi-external model. Extensive experiments, conducted on four real temporal networks, demonstrate the efficiency and effectiveness of our proposed algorithms. For example, on the DBLP dataset, I/O-LS and LS-EBCS have comparable running time, while the maximum memory usage of I/O-LS is only 6.5 MB, which is much smaller than that of LS-EBCS taking 308.7 MB.
Supplementary Information: The online version contains supplementary material available at 10.1007/s11390-022-2367-3.
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http://dx.doi.org/10.1007/s11390-022-2367-3 | DOI Listing |
CNS Neurosci Ther
September 2025
Department of Functional Neurosurgery, Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Aim: A total of 30% of individuals with epilepsy are resistant to drug treatment. Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) shows promise for treating drug-resistant epilepsy (DRE), but further research is needed to optimize DBS parameters, including stimulation frequency. This study aimed to reveal the optimal frequency for ANT-DBS by testing the real-time effects of various stimulation frequencies on the ANT among patients undergoing stereoelectroencephalography (SEEG) electrode implantation.
View Article and Find Full Text PDFVirology
August 2025
ICMR-National Institute of Virology, 130/1, Sus Road, Pashan, Pune, 411021, India; ICMR-National Institute of Virology, 20/A, Dr. Ambedkar Road, Pune, 411001, India.
Highly pathogenic avian influenza (HPAI) clade 2.3.4.
View Article and Find Full Text PDFTransl Behav Med
January 2025
Ingram School of Nursing, Faculty of Medicine and Health Sciences, McGill University, Montréal, Canada.
Background: Theories, models, and frameworks (TMFs) are central to the development and evaluation of implementation strategies supporting evidence-based practice (EBP). However, evidence on how and to what extent TMFs are used in implementation trials remains limited.
Purpose: This study aimed to examine the nature and extent of TMF use in implementation trials, identify which TMFs are most frequently employed, and explore temporal trends in their use.
Neurobiol Dis
September 2025
Farber Institute for Neuroscience, Department of Neurology, Thomas Jefferson University; Philadelphia, PA, USA. Electronic address:
Temporal lobe epilepsy (TLE) patients experience shifts between non-seizing and seizing brain states, but the structural networks underlying these transitions remain undefined and poorly characterized. We detected dynamic brain states in resting-state fMRI and constructed linked structural networks utilizing multi-shell diffusion-weighted MR data. Leveraging network control theory, we interrogated the structural data for all possible brain state transitions, identifying those requiring abnormal levels of transition energy (low or high) in TLE compared to matched healthy participants (n's = 25).
View Article and Find Full Text PDFNeurobiol Dis
September 2025
Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China. Electronic address:
The effect of recurrent seizures on the gradual deterioration of the white matter structural network and the potential molecular mechanisms that underlie the baseline and longitudinal changes in network topology in temporal lobe epilepsy (TLE) remain unclear. Therefore, we used diffusion tensor imaging (DTI) scans and neuropsychiatric assessments for 28 patients with unilateral TLE at baseline and follow-up, and for 28 healthy controls (HC). The topological properties of the structural network were calculated using graph theoretical analyses.
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