Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In early gastric cancer (EGC) patients, lymph node metastasis (LNM) risk assessment is particularly important for the selection of surgical methods. In this study, we investigated the correlation between gastritis cystica profunda (GCP) and the risk of LNM in EGC. From January 2014 to December 2019, EGC patients who underwent curative radical gastrectomy were enrolled in this study. The clinicopathological features were analyzed, and the correlation between GCP and the risk of lymph node metastasis was assessed. Data for 180 EGC patients were analyzed, and 17.8% (32/180) had LNM. The incidence of LNM was 2.6% in the GCP-positive group and 21.8% in the GCP-negative group. Univariate analysis revealed that GCP, depth of tumor invasion, and lymphovascular invasion were the risk factors of LNM in EGC patients. Multiple regression analysis showed that GCP was associated with the risk of LNM in EGC patients (OR=0.097, 0.121, 0.100, p<0.05). The curve fitting results showed that there was a negative correlation between the GCP and LNM in EGC, which was consistent between different tumor sites, size, ulceration, differentiation types, depth of tumor invasion, lymphovascular invasion, and no significant interaction was found among these factors (p for interaction range 0.224-0.717). GCP is closely related to LNM in EGC. Preoperative assessment of whether EGC is combined with GCP is beneficial for the assessment of the risk of LNM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4149/neo_2022_220314N281 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparison of the two intestinal anastomosis methods in pediatric patients.
Open Med (Wars)
August 2025
Department of Pediatric Surgery, Women and Children's Hospital, Chongqing Medical University, #120 Longshan Rd. Yubei, Chongqing, 401147, P. R. China.
Background: For pediatric patients, there is still controversy regarding the anastomotic technique used for gastrointestinal construction. The study was to evaluate the continuous single-layer (CSL) intestinal anastomosis method compared with the two-layered interrupted anastomosis.
Methods: We retrospectively reviewed the medical records of the eligible patients following CSL anastomosis ( = 252) and interrupted double-layer (IDL) anastomosis ( = 196).
Neuro-immuno-stromal context in colorectal cancer: An enteric glial cell-driven prognostic model via machine learning predicts survival, recurrence, and therapy response.
Exp Cell Res
September 2025
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Cancer Center, Peking University Cancer Hospital and Institute, Beijing, China. Electronic address:
Background: Enteric glial cells (EGCs) have been implicated in colorectal cancer (CRC) progression. This study aimed to develop and validate a prognostic model integrating EGC- and CRC-associated gene expression to predict patient survival, recurrence, metastasis, and therapy response.
Methods: Bulk and single-cell RNA sequencing data were analyzed, and a machine learning-based model was constructed using the RSF random forest algorithm.
Retrospective study of the characteristics of early gastric cancer with surrounding map-like redness after successful Helicobacter pylori eradication.
J Cancer Res Ther
September 2025
Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
Background: Map-like redness (MLR) is a high-risk membrane factor for early gastric cancer (EGC) after the successful eradication of Helicobacter pylori (Hp). This study aimed to analyze the clinical, endoscopic, and pathological characteristics of EGC with surrounding MLR after successful Hp eradication and evaluate the effect of endoscopic submucosal dissection (ESD) resection.
Methods: This retrospective study comprised 23 patients with EGC and surrounding MLR after Hp eradication (MLR group) and 135 patients with EGC without a surrounding MLR (non-MLR; NMLR group).
Prognostic value of signet-ring cell carcinoma proportion in undifferentiated gastric cancer: Implications for endoscopic treatment decisions.
World J Gastroenterol
August 2025
Department of Pathology, Seoul National University Bundang Hospital, Seongnam-si 13620, Gyeonggi-do, South Korea.
Background: Poorly cohesive gastric carcinomas are classified based on the proportion of signet-ring cell carcinoma (SRCC) components. In surgically resected gastric cancer, SRCC is diagnosed when the signet-ring cell (SRC) component constitutes ≥ 50% of the entire tumor, whereas poorly cohesive carcinoma (PCC) not otherwise specified is diagnosed when the proportion of the SRC component is < 50% of the entire tumor. The SRCC proportion in PCC varies along the spectrum, and its prognostic significance in gastric cancer remains unclear.
View Article and Find Full Text PDFUsefulness of Underwater Endoscopic Mucosal Resection Compared With Conventional Endoscopic Mucosal Resection for Early Gastric Cancer.
J Gastroenterol Hepatol
September 2025
Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
Background And Aims: Endoscopic mucosal resection (EMR) is one of the standard treatments for small early gastric cancer (EGC) but has a low R0 resection rate. Consequently, underwater EMR (UEMR) has become the new standard treatment for endoscopic resection of colorectal and duodenal tumors; however, no study has compared the effectiveness of UEMR and conventional EMR (CEMR) for EGC. Therefore, in this study, we aimed to evaluate the usefulness of UEMR for EGC compared with that of CEMR.
View Article and Find Full Text PDF