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Introduction: Ovarian granulosa cell tumor is a relatively rare tumor that accounts for 2-5% of malignant ovarian tumors. This tumor progresses slowly and may recur late in life.
Case Presentation: A 70-year-old woman was admitted to our hospital with a left secondary pneumothorax due to metastatic lung tumors of granulosa cell tumor. Reports of secondary pneumothorax due to granulosa cell tumor are rare. Thoracoscopic suturing and pleurodesis using talc were effective in the treatment of this pneumothorax.
Conclusions: We experienced a rare case of secondary pneumothorax due to multiple pulmonary metastases of granulosa cell tumor. It should be noted that pulmonary metastasis of granulosa cell tumor can lead to secondary pneumothorax.
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http://dx.doi.org/10.4081/mrm.2022.884 | DOI Listing |
Am J Reprod Immunol
September 2025
Department of Molecular Biology and Genetics, Tokat Gaziosmanpasa University, Tokat, Turkey.
J Cell Mol Med
September 2025
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Diminished ovarian reserve (DOR) poses significant challenges in reproductive health, with emerging evidence implicating DNA damage repair pathways. While GADD45A is a critical regulator of DNA repair, cell cycle and apoptosis, its role in DOR pathogenesis remains unexplored. We employed transcriptome sequencing, qPCR and Western Blot analyses to compare GADD45A expression in granulosa cells (GCs) between DOR patients and controls.
View Article and Find Full Text PDFAnim Reprod Sci
September 2025
Department of Animal Physiology and Endocrinology, University of Agriculture in Krakow, Al. Mickiewicza 24/28, Krakow 30-059, Poland.
Irisin, a myokine/adipokine released during physical activity, has attracted attention for its regulatory effects on various physiological processes, including metabolism and reproduction. This study was performed to investigate the presence of fibronectin type III domain-containing protein 5 (FNDC5) in chicken granulosa cells (GCs) using immunocytochemistry and to assess the effect of irisin, the extracellular fragment of FNDC5, on these cells, which play a crucial role in progesterone (P4) production and follicle maturation. We measured cell viability, mRNA expression of the luteinising hormone receptor (LHR), the expression of steroidogenic genes (StAR, CYP11A1, and 3BHSD), and P4 secretion in GCs of chicken ovarian follicles.
View Article and Find Full Text PDFJ Obstet Gynaecol
December 2025
Division of Minimally Invasive Gynaecologic Surgery, Baylor College of Medicine, Houston, Texas, USA.
Background: Robotic single-port transvaginal natural orifice transluminal endoscopic surgery (RSP-vNOTES) is an emerging minimally invasive approach that combines the advantages of robotic surgery with scarless transvaginal access. Its application in gynecologic oncology remains limited, particularly for omentectomy during ovarian cancer staging.
Methods: We present the case of a 45-year-old woman with an ovarian granulosa cell tumor (GCT) who underwent supplemental staging surgery following unilateral oophorectomy.
Reprod Sci
September 2025
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Baotou Medical College, No. 30 Hudemulin Street, Qingshan District, Baotou, 014030, Inner Mongolia, China.
PCOS refers to an endocrine and metabolic disorder that affects female individuals of reproductive age. Our study explores the potential mechanism of circ_0070987 on PCOS in regulating pyroptosis of ovarian GCs, providing new evidence for PCOS treatment. PCOS cell model was established.
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