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http://dx.doi.org/10.1007/s00401-022-02534-0 | DOI Listing |
Physiol Rep
September 2025
Division of Pulmonary, Critical Care, Sleep, and Allergy Medicine, University of Arizona, Tucson, Arizona, USA.
Post-acute sequelae of SARS-CoV-2 (PASC or "long COVID") and chronic fatigue syndrome/myalgic encephalitis (CFS/ME) share symptoms such as exertional dyspnea. We used exercise oxygen pathway analysis, comprising six parameters of oxygen transport and utilization, to identify limiting mechanisms in both conditions. Invasive cardiopulmonary exercise testing was performed on 15 PASC patients, 11 CFS/ME patients, and 11 controls.
View Article and Find Full Text PDFAlzheimers Dement
September 2025
Talisman Therapeutics, Babraham Research Campus, Cambridge, UK.
Introduction: Mutations in the MAPT gene that are causal for frontotemporal dementia (FTD) lead to mislocalization of tau protein to the neuronal cell body, changing microtubule dynamics to disrupt the nuclear envelope and nucleocytoplasmic transport.
Methods: We report a high content imaging-based phenotypic screen to identify novel small molecules that correct nuclear envelope defects in human neurons expressing the MAPT IVS10+16 mutation causal for FTD.
Results: Screening a 19,786-compound chemical diversity library, we identified > 100 compounds that corrected nuclear membrane defects in MAPT IVS10+16 neurons, with 23 demonstrating robust dose-dependent rescue.
Cell Death Differ
September 2025
Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Clin Neurol Neurosurg
October 2025
Department of Psychology, Islamic Azad University of Torbat-e Jam, Mashhad, Iran.
Background: Alzheimer's disease (AD) is characterized by a complex interplay between amyloid-β (Aβ) and tau pathologies, with increasing evidence implicating cerebral blood flow (CBF) alterations as a critical, yet underexplored, contributor to disease progression. This study aimed to investigate the associations between regional CBF and cerebrospinal fluid (CSF) biomarkers- Aβ1-42, total tau (T-Tau), and phosphorylated tau (P-Tau181)-across the AD continuum.
Methods: We conducted a cross-sectional analysis using data from 416 participants enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI), including cognitively normal individuals, patients with mild cognitive impairment (MCI), and those with AD.
Bioengineering (Basel)
July 2025
Cerebrovascular Disease Department, Neurological Disease Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Alzheimer's disease (AD) and ischemic stroke (IS) are prevalent neurological disorders that frequently co-occur in the same individuals. Recent studies have demonstrated that AD and IS share several common risk factors and pathogenic elements, including an overlapping genomic architecture. However, the relationship between IS risk gene polymorphisms and AD has been less extensively studied.
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